Grubb A, Simonsen O, Sturfelt G, Truedsson L, Thysell H
Acta Med Scand. 1985;218(5):499-503. doi: 10.1111/j.0954-6820.1985.tb08880.x.
Serum concentrations of creatinine and of the three low molecular weight (LMW) proteins cystatin C, factor D of the complement system and beta 2-microglobulin were measured in 135 consecutive patients, whose glomerular filtration rates (GFR) were determined by Cr-EDTA. In the total patient series, the reciprocals of S-creatinine and S-cystatin C were numerically and, in males, significantly more closely correlated to GFR than the reciprocals of S-factor D. The reciprocals of beta 2-microglobulin showed a weaker correlation to GFR than those of the other three substances. The calculated glomerular elimination rates of creatinine, cystatin C and factor D were normally distributed, in contrast to those of beta 2-microglobulin. According to data presented so far, cystatin C seems to be the LMW protein of first choice when GFR is to be estimated by measuring the plasma concentration of a LMW protein.
对135例连续患者测定了血清肌酐以及三种低分子量（LMW）蛋白——胱抑素C、补体系统因子D和β2-微球蛋白的浓度，这些患者的肾小球滤过率（GFR）通过Cr-EDTA测定。在整个患者系列中，血清肌酐（S-肌酐）和血清胱抑素C倒数的数值与GFR的相关性，在男性中显著高于血清因子D的倒数。β2-微球蛋白的倒数与GFR的相关性比其他三种物质的倒数弱。与β2-微球蛋白不同，计算得出的肌酐、胱抑素C和因子D的肾小球清除率呈正态分布。根据目前所呈现的数据，当通过测量低分子量蛋白的血浆浓度来估算GFR时，胱抑素C似乎是首选的低分子量蛋白。
