Simonsen O, Grubb A, Thysell H
Scand J Clin Lab Invest. 1985 Apr;45(2):97-101. doi: 10.3109/00365518509160980.
The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.
对106例患者测定了血清肌酐以及低分子量蛋白胱抑素C、β2-微球蛋白和视黄醇结合蛋白的浓度，这些患者的肾小球滤过率通过铬-乙二胺四乙酸（EDTA）清除率测定来评估。血清肌酐、胱抑素C和β2-微球蛋白浓度的倒数与铬-EDTA清除率密切相关（分别为r = 0.73、0.75和0.70），而视黄醇结合蛋白的相应值则不然（r = 0.39）。肌酐和胱抑素C的肾小球清除率计算值呈正态分布，与β2-微球蛋白的情况不同。胱抑素C的计算肾小球清除率与年龄、性别、疾病类型或疾病活动度均无相关性。结果表明，与β2-微球蛋白的血清水平相比，胱抑素C的血清水平是肾小球滤过率的更好指标。
