Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Limburg Clinical Research Center, Hasselt University, Genk, Belgium.
EBioMedicine. 2024 Sep;107:105253. doi: 10.1016/j.ebiom.2024.105253. Epub 2024 Aug 22.
Nephron number variability may hold significance in the Developmental Origins of Health and Disease hypothesis. We explore the impact of gestational particulate pollution exposure on cord blood cystatin C, a marker for glomerular function, as an indicator for glomerular health at birth.
From February 2010 onwards, the ENVIRONAGE cohort includes over 2200 mothers giving birth at the East-Limburg hospital in Genk, Belgium. Mothers without planned caesarean section who are able to fill out a Dutch questionnaire are eligible. Here, we evaluated cord blood cystatin C levels from 1484 mother-child pairs participating in the ENVIRONAGE cohort. We employed multiple linear regression models and distributed lag models to assess the association between cord blood cystatin C and gestational particulate air pollution exposure.
Average ± SD levels of cord blood cystatin C levels amounted to 2.16 ± 0.35 mg/L. Adjusting for covariates, every 0.5 μg/m³ and 5 μg/m³ increment in gestational exposure to black carbon (BC) and fine particulate matter (PM) corresponded to increases of 0.04 mg/L (95% CI 0.01-0.07) and 0.07 mg/L (95% CI 0.03-0.11) in cord blood cystatin C levels (p < 0.01), respectively. Third-trimester exposure showed similar associations, with a 0.04 mg/L (95% CI 0.00-0.08) and 0.06 mg/L (95% CI 0.04-0.09) increase for BC and PM (p < 0.02). No significant associations were observed when considering only the first and second trimester exposure.
Our findings indicate that particulate air pollution during the entire pregnancy, with the strongest effect sizes from week 27 onwards, may affect newborn kidney function, with potential long-term implications for later health.
Special Research Fund (Bijzonder Onderzoeksfonds, BOF), Flemish Scientific Research Fund (Fonds Wetenschappelijk Onderzoek, FWO), and Methusalem.
肾单位数量的变化可能在健康与疾病的发育起源假说中具有重要意义。我们探讨了妊娠期颗粒状污染物暴露对脐血胱抑素 C 的影响，胱抑素 C 是肾小球功能的标志物，可作为出生时肾小球健康的指标。
自 2010 年 2 月起，ENVIRONAGE 队列纳入了 2200 多名在比利时根特东利姆堡医院分娩的母亲。有计划剖宫产的母亲和无法填写荷兰问卷的母亲不符合入组条件。在这里，我们评估了参与 ENVIRONAGE 队列的 1484 对母婴对的脐血胱抑素 C 水平。我们采用多元线性回归模型和分布滞后模型来评估脐血胱抑素 C 与妊娠期颗粒状空气污染暴露之间的关系。
脐血胱抑素 C 水平的平均±标准差水平为 2.16±0.35mg/L。调整协变量后，妊娠期黑碳（BC）和细颗粒物（PM）暴露每增加 0.5μg/m³和 5μg/m³，脐血胱抑素 C 水平分别增加 0.04mg/L（95%CI 0.01-0.07）和 0.07mg/L（95%CI 0.03-0.11）（p<0.01）。第三孕期的暴露也存在类似的关联，BC 和 PM 的暴露分别增加了 0.04mg/L（95%CI 0.00-0.08）和 0.06mg/L（95%CI 0.04-0.09）（p<0.02）。仅考虑第一和第二孕期的暴露时，没有观察到显著的关联。
我们的研究结果表明，整个孕期的颗粒状空气污染，尤其是从 27 周开始的最强效应，可能会影响新生儿的肾功能，对以后的健康有潜在的长期影响。
特殊研究基金（Bijzonder Onderzoeksfonds，BOF）、佛兰德科学研究基金（Fonds Wetenschappelijk Onderzoek，FWO）和梅瑟斯缪斯。
