Suzuki K, Tamai H
Hinyokika Kiyo. 1985 Oct;31(10):1885-94.
Prior to clinical investigations, in vitro activities of 5-fluorocytosine (5-FC), ofloxacin (OFLX), and the combination on a strain of E. coli and of C. albicans were tested. The two drugs showed highly active on each target strain without any interaction. In clinical studies, 5 female adult patients with persistent uncomplicated UTI (3 of cystitis, 2 of pyelonephritis) caused by polymicrobial organisms (including bacteria and fungi) were treated in combination of 5-FC and oral chemotherapeutic agent. The results were both bacteriologically and symptomatically successful in all of 5 cases. Those had been poor by other antibiotic drugs in single use or 5-FC alone. Consequently, 5-FC and oral antibacterial drug combination was useful in therapy on even uncomplicated UTI due to polymicrobial organisms including fungi.
在进行临床研究之前，测试了5-氟胞嘧啶（5-FC）、氧氟沙星（OFLX）及其组合对一株大肠杆菌和白色念珠菌的体外活性。这两种药物对每种靶菌株均显示出高活性，且无任何相互作用。在临床研究中，对5名由多种微生物（包括细菌和真菌）引起的持续性单纯性尿路感染的成年女性患者（3例膀胱炎，2例肾盂肾炎）采用5-FC与口服化疗药物联合治疗。5例患者的治疗在细菌学和症状方面均取得成功。这些病例单独使用其他抗生素药物或单独使用5-FC时效果不佳。因此，5-FC与口服抗菌药物联合使用对治疗包括真菌在内的多种微生物引起的单纯性尿路感染有效。
