Ul Ain Noor, Naveed Muhammad, Aziz Tariq, Shabbir Muhammad Aqib, Al Asmari Fahad, Abdi Gholamreza, Sameeh Manal Y, Alhhazmi Areej A
Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.
Laboratory of Animal Health, Food Hygiene and Quality Department of Agriculture, University of Ioannina, 47100, Arta, Greece.
Sci Rep. 2024 Aug 8;14(1):18397. doi: 10.1038/s41598-024-69515-z.
Antibiotics, improper food, and stress have created a dysbiotic state in the gut and almost 81% of the world's population has been affected due to the pandemic of COVID-19 and the prevalence of dengue virus in the past few years. The main intent of this study is to synthesize nanosynbiotics as nu traceuticals by combining probiotics, and prebiotics with nanoformulation. The effectiveness of the nanosynbiotics was evaluated using a variety of Nutra-pharmacogenetic assays leading to an AI-integrated formulation profiling was assessed by using machine learning methods. Consequently, Acetobacter oryzoeni as a probiotic and inulin as a prebiotic has been chosen and iron-mediated nanoformulation of symbiotic is achieved. Nanosynbiotics possessed 89.4, 96.7, 93.57, 83.53, 88.53% potential powers of Nutra-pharmacogenetic assays. Artificial intelligent solid dispersion formulation of nanosynbiotics has high dissolution, absorption, distribution, and synergism, in addition, they are non-tox, non-allergen and have a docking score of - 10.83 kcal/mol, implying the best interaction with Pregnane X receptor involved in dysbiosis. The potential of nanosynbiotics to revolutionize treatment strategies through precise targeting and modulation of the gut microbiome for improved health outcomes and disease management is promising. Their transformational influence is projected to be powered by integration with modern technology and customized formulas. Further in-vivo studies are required for the validation of nanosynbiotics as nutraceuticals.
抗生素、不当饮食和压力已在肠道中造成了生态失调状态，并且由于新冠疫情以及过去几年登革热病毒的流行，全球近81%的人口受到了影响。本研究的主要目的是通过将益生菌、益生元与纳米制剂相结合来合成纳米合生元作为营养保健品。使用多种营养药物遗传学分析评估了纳米合生元的有效性，并通过机器学习方法评估了导致人工智能整合制剂剖析的情况。因此，选择了米根醋酸杆菌作为益生菌，菊粉作为益生元，并实现了铁介导的共生纳米制剂。纳米合生元具有营养药物遗传学分析的89.4%、96.7%、93.57%、83.53%、88.53%的潜在能力。纳米合生元的人工智能固体分散体制剂具有高溶解性、吸收性、分布性和协同性，此外，它们无毒、无过敏原，对接分数为-10.83千卡/摩尔，这意味着与参与生态失调的孕烷X受体有最佳相互作用。纳米合生元通过精确靶向和调节肠道微生物群以改善健康结果和疾病管理来彻底改变治疗策略的潜力是巨大的。预计它们的变革性影响将由与现代技术和定制配方的整合来推动。需要进一步的体内研究来验证纳米合生元作为营养保健品的有效性。
