Eze Osita C, Berebon Dinebari P, Emencheta Stephen C, Evurani Somtochukwu A, Okorie Chibundo N, Balcão Victor M, Vila Marta M D C
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria.
PhageLab-Laboratory of Biofilms and Bacteriophages, University of Sorocaba, Sorocaba 18023-000, Brazil.
Pharmaceuticals (Basel). 2023 Aug 1;16(8):1091. doi: 10.3390/ph16081091.
Due to the increasing limitations and negative impacts of the current options for preventing and managing diseases, including chemotherapeutic drugs and radiation, alternative therapies are needed, especially ones utilizing and maximizing natural products (NPs). NPs abound with diverse bioactive primary and secondary metabolites and compounds with therapeutic properties. Marine probiotics are beneficial microorganisms that inhabit marine environments and can benefit their hosts by improving health, growth, and disease resistance. Several studies have shown they possess potential bioactive and therapeutic actions against diverse disease conditions, thus opening the way for possible exploitation of their benefits through their application. spp. are a widely distributed heterotrophic, flagellated, non-spore-forming, rod-shaped, and gram-negative marine probiotic bacteria species with reported therapeutic capabilities, including anti-cancer and -bacterial effects. This review discusses the basic concepts of marine probiotics and their therapeutic effects. Additionally, a survey of the anticancer and antibacterial effects of spp. is presented. Finally, marine probiotic production, advances, prospects, and future perspectives is presented.
由于当前疾病预防和管理方法(包括化疗药物和放疗)的局限性日益增加且负面影响不断,需要替代疗法,特别是利用天然产物(NPs)并使其最大化的疗法。天然产物富含多种具有治疗特性的生物活性初级和次级代谢产物及化合物。海洋益生菌是栖息于海洋环境中的有益微生物,可通过改善健康、促进生长和增强抗病能力使宿主受益。多项研究表明,它们对多种疾病状况具有潜在的生物活性和治疗作用,从而为通过应用来开发其益处开辟了道路。 spp. 是一种广泛分布的异养、具鞭毛、无芽孢形成、杆状且革兰氏阴性的海洋益生菌种,具有包括抗癌和抗菌作用在内的已报道治疗能力。本综述讨论了海洋益生菌的基本概念及其治疗作用。此外,还介绍了 spp. 的抗癌和抗菌作用研究。最后,阐述了海洋益生菌的生产、进展、前景及未来展望。