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一种治疗罗伯特子宫腺肌病的新方法:病例报告及文献复习。

A new treatment for Robert's uterus with adenomyosis: a case report and review of the literature.

机构信息

Gynecology Department, Xuan Cheng People's Hospital, Xuan Cheng, An hui Province, China.

出版信息

BMC Womens Health. 2024 Aug 8;24(1):450. doi: 10.1186/s12905-024-03286-7.

DOI:10.1186/s12905-024-03286-7
PMID:39118092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11308425/
Abstract

PURPOSE

To provide a method for the differential diagnosis of Robert's uterus with adenomyosis, a rare uterine malformation, and determine the best course of treatment.

METHODS

A patient who had Robert's uterus with adenomyosis was admitted to our hospital in December 2022. We analyzed and summarized her case .

RESULTS

Our patient complained of progressively worsening primary dysmenorrhea over the course of 3 years and lower abdominal pain lasting for 2 days. Her carbohydrate antigen 125 (CA125) level was 372.10 U/mL. Examinations conducted by several hospitals indicated that she had a single-horned uterus and a residual horned uterus, and our hospital's examination identified Robert's uterus. This malformation was corrected by open abdominal surgery. For the procedure, pelvic adhesions were first isolated, after which the closed uterine cavity and adenomyosis were resected. Subsequently, the left ovarian endometriosis cyst was resected and right tubal ligation was performed. After surgery, three injections of gonadotropin-releasing hormone A (GnRH-A) were administered, which lowered the patient's CA125 level to 14 U/mL and normalized her condition.

CONCLUSION

We pioneered a new therapeutic approach for the treatment of Robert's uterus with adenomyosis. Some valuable references are provided for clinical practice.

摘要

目的

为罕见的子宫畸形——Robert 子宫伴腺肌病的鉴别诊断提供一种方法,并确定最佳治疗方案。

方法

我们于 2022 年 12 月收治了 1 例 Robert 子宫伴腺肌病患者,对其病例进行了分析和总结。

结果

患者 3 年来痛经进行性加重,2 天前出现下腹疼痛,糖类抗原 125(CA125)水平为 372.10 U/mL。多家医院检查均提示单角子宫伴残角子宫,我院检查诊断为 Robert 子宫。该畸形采用开腹手术矫正,先行盆腔粘连松解,切除封闭的宫腔及腺肌症,然后切除左侧卵巢子宫内膜异位囊肿,行右侧输卵管结扎术。术后给予 3 针促性腺激素释放激素 A(GnRH-A)注射,使 CA125 水平降至 14 U/mL,病情缓解。

结论

我们开创了治疗 Robert 子宫伴腺肌病的新方法,为临床实践提供了一些有价值的参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/df7479cf31f7/12905_2024_3286_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/2287ff87b4e5/12905_2024_3286_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/9f52db453626/12905_2024_3286_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/8084ebec9951/12905_2024_3286_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/df7479cf31f7/12905_2024_3286_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/2287ff87b4e5/12905_2024_3286_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/9f52db453626/12905_2024_3286_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/8084ebec9951/12905_2024_3286_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/11308425/df7479cf31f7/12905_2024_3286_Fig4_HTML.jpg

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本文引用的文献

1
Guideline No. 437: Diagnosis and Management of Adenomyosis.指南第 437 号:子宫腺肌病的诊断与管理。
J Obstet Gynaecol Can. 2023 Jun;45(6):417-429.e1. doi: 10.1016/j.jogc.2023.04.008.
2
Concurrent Diagnosis of Adenomyosis and Congenital Uterine Anomalies: A Review.子宫腺肌病与先天性子宫异常的同时诊断:综述
J Pers Med. 2023 Apr 24;13(5):716. doi: 10.3390/jpm13050716.
3
Ultrasound combined with hysteroscopy for optimum treatment of Robert's uterus: a case report and a review.超声联合宫腔镜治疗罗伯逊氏子宫:病例报告及文献复习。
BMC Womens Health. 2022 Aug 7;22(1):334. doi: 10.1186/s12905-022-01903-x.
4
Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review.姜黄素、槲皮素或白藜芦醇对子宫内膜异位症病理生理学的影响:系统评价。
Phytother Res. 2022 Jun;36(6):2416-2433. doi: 10.1002/ptr.7464. Epub 2022 May 18.
5
Imaging features of Robert's uterus: Case series of a rare Mullerian duct anomaly.罗伯特氏子宫影像学特征:一种罕见的苗勒管畸形病例系列。
Trop Doct. 2021 Oct;51(4):553-560. doi: 10.1177/00494755211034061. Epub 2021 Jul 27.
6
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: a comprehensive update. Mayer-Rokitansky-Küster-Hauser(MRKH)综合征:全面更新。
Orphanet J Rare Dis. 2020 Aug 20;15(1):214. doi: 10.1186/s13023-020-01491-9.
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Hysteroscopic Management of Robert's Uterus.罗伯特子宫的宫腔镜治疗
J Obstet Gynaecol India. 2020 Feb;70(1):86-88. doi: 10.1007/s13224-019-01208-4. Epub 2019 Mar 8.
8
Pre-, intra-, and postoperative management of Robert's uterus.罗伯逊子宫的术前、术中和术后处理。
Fertil Steril. 2018 Sep;110(4):778-779. doi: 10.1016/j.fertnstert.2018.05.033.
9
Ultrasonic evaluation of congenital vaginal oblique septum syndrome: A study of 21 cases.先天性阴道斜隔综合征的超声评估:21例研究
Exp Ther Med. 2018 Sep;16(3):2066-2070. doi: 10.3892/etm.2018.6411. Epub 2018 Jul 6.
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ACOG Committee Opinion No. 728: Müllerian Agenesis: Diagnosis, Management, And Treatment.美国妇产科医师学会委员会意见第728号:苗勒管发育不全:诊断、管理与治疗
Obstet Gynecol. 2018 Jan;131(1):e35-e42. doi: 10.1097/AOG.0000000000002458.