代谢综合征与老年急性呼吸窘迫综合征患者的死亡率相关。
Metabolic syndrome is associated with mortality in elderly patients with acute respiratory distress syndrome.
作者信息
Xu Xiao, Xu Huajuan, Li Ming, Yan Shuying, Chen Huilin
机构信息
Intensive Care Unit (ICU), Shanghai Construction Group Hospital, No. 666, North Zhongshan Road Number One, Hongkou District, Shanghai, 200083, China.
出版信息
Diabetol Metab Syndr. 2024 Aug 8;16(1):191. doi: 10.1186/s13098-024-01420-x.
BACKGROUND
This study aims to evaluate the association of metabolic syndrome (MetS) with the risk of all-cause mortality in elderly patients with acute respiratory distress syndrome (ARDS).
METHODS
Elderly ARDS patients (≥ 65 years) enrolled from our hospital between January 2018 and July 2023 were divided into the MetS group or the non-MetS group. The outcomes were 28-day and 90-day all-cause mortality rates in the total population and two subgroups stratified by age (65-75 years and ≥ 75 years). Multivariate Cox regression was employed to assess the association of MetS with all-cause mortality, after controlling for potential cofounding factors.
RESULTS
A total of 946 patients were divided into the MetS group (n = 410) or the non-MetS group (n = 536). The 28-day and 90-day all-cause mortality rates were significantly higher for MetS group compared to non-MetS group in the total population and two subgroups (all P < 0.01). Multivariate Cox regression indicated that MetS was significantly associated with a higher risk of 90-day all-cause mortality in the total population (HR = 1.62, 95% CI: 1.22-2.15; P < 0.01), and subgroups of patients aged 65-75 years (HR = 1.52, 95% CI: 1.04-2.21; P = 0.03) and ≥ 75 years (HR = 1.90, 95% CI: 1.23-2.94; P < 0.01). Moreover, with each MetS criterion added from 0 to 1 to 2, 3, and 4 of 4 criteria, both 28-day and 90-day all-cause mortality rates significantly increased (both P < 0.01).
CONCLUSION
MetS was associated with higher risks of 28-day and 90-day all-cause mortality in elderly patients with ARDS.
背景
本研究旨在评估代谢综合征（MetS）与老年急性呼吸窘迫综合征（ARDS）患者全因死亡风险之间的关联。
方法
选取2018年1月至2023年7月期间我院收治的老年ARDS患者（≥65岁），分为MetS组和非MetS组。观察指标为总体人群以及按年龄分层的两个亚组（65 - 75岁和≥75岁）的28天和90天全因死亡率。在控制潜在混杂因素后，采用多因素Cox回归分析评估MetS与全因死亡率的关联。
结果
共946例患者分为MetS组（n = 410）和非MetS组（n = 536）。总体人群及两个亚组中，MetS组的28天和90天全因死亡率均显著高于非MetS组（均P < 0.01）。多因素Cox回归分析表明，MetS与总体人群90天全因死亡风险显著相关（HR = 1.62，95%CI：1.22 - 2.15；P < 0.01），在65 - 75岁亚组（HR = 1.52，95%CI：1.04 - 2.21；P = 0.03）和≥75岁亚组（HR = 1.90，95%CI：1.23 - 2.94；P < 0.01）中也是如此。此外，随着MetS标准从4项标准中的0项增加到1项、2项、3项和4项，28天和90天全因死亡率均显著升高（均P < 0.01）。
结论
MetS与老年ARDS患者28天和90天全因死亡风险较高相关。
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