Respiratory and Critical Care Medicine, Regional Medical Center for National Institute of Respiratory Disease, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University.
Cancer Center, Zhejiang University, Hangzhou, China.
Clin Respir J. 2024 Aug;18(8):e13816. doi: 10.1111/crj.13816.
Helicobacter pylori (H. pylori) infection is currently widespread throughout the world. Bismuth-containing quadruple therapy is widely used, but it has rarely been associated with interstitial lung disease.
We described six cases with similar clinical symptoms and typical pulmonary interstitial imaging changes during anti-H. pylori therapy, usually on Days 7-12 following treatment. Anti-H. pylori infection treatment was discontinued when it was suspected to be the cause of the clinical symptoms, and all of the patients accepted observation therapy. All of them had a favorable outcome, the clinical symptoms returned to normal almost 1 week later, and the chest computed tomography (CT) scan images showed remarkable absorption 4 weeks later.
Drug interactions could be the cause, and the most likely drug was furazolidone. All of the patients recovered quickly after drug discontinuation, and low-dose steroid may help shorten the recovery time.
幽门螺杆菌（H. pylori）感染目前在全球范围内广泛存在。含铋的四联疗法被广泛应用，但很少与间质性肺病相关。
我们描述了 6 例在抗 H. pylori 治疗期间出现类似临床症状和典型肺间质影像学改变的病例，通常在治疗后第 7-12 天。当怀疑临床症状是由感染治疗引起时，停止了抗 H. pylori 感染治疗，所有患者均接受观察治疗。所有患者的结局均良好，临床症状在近 1 周后恢复正常，胸部计算机断层扫描（CT）图像显示 4 周后明显吸收。
药物相互作用可能是病因，最有可能的药物是呋喃唑酮。所有患者在停药后均迅速恢复，小剂量类固醇可能有助于缩短恢复时间。
