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探索调节性T细胞与动脉粥样硬化形成中炎性细胞因子之间的联系：来自稳定型心绞痛患者的研究结果。

Exploring the link between T-regulatory cells and inflammatory cytokines in atherogenesis: findings from patients with stable angina pectoris.

作者信息

Tahtouh Zaatar Muriel, Othman Rima, Abou Samra Elias, Karam Marc

机构信息

Department of Biological and Physical Sciences, American University in Dubai, Dubai, United Arab Emirates.

Department of Biology, University of Balamand, Balamand, Lebanon.

出版信息

Ann Med Surg (Lond). 2024 Jun 4;86(8):4456-4462. doi: 10.1097/MS9.0000000000002150. eCollection 2024 Aug.

DOI:10.1097/MS9.0000000000002150
PMID:39118685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11305802/
Abstract

BACKGROUND

Atherosclerosis, a chronic inflammatory disease impacting arteries, is closely linked to cardiovascular conditions. Dyslipidemia, marked by high low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and increased plasma triglycerides, is a key risk factor. Atherogenesis begins when modified lipoproteins like oxidized LDL (ox-LDL) activate the immune system. This study explores the roles of T-regulatory cells (Tregs) and interleukins 10 (IL-10), 6 (IL-6), and 17 (IL-17) in atherogenesis.

METHODS

Samples were collected from the Hospital patients with stable angina pectoris (SAP). Peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll density gradient and analyzed via flow cytometry. IL-10, IL-6, and IL-17 levels in cell culture supernatant were measured using ELISA. Data were expressed as mean ± SEM and analyzed with statistical software.

RESULTS

Results indicate that only patients exhibited reduced Treg and IL-10 levels after high-dose ox-LDL treatment. Significant IL-6 reduction was observed in both NCA and SA groups after high-dose n-LDL and low/high ox-LDL treatments compared to untreated PBMCs.

CONCLUSIONS AND FUTURE DIRECTIONS

Future research will explore n-LDL and ox-LDL effects on Th17/Treg immune responses within a specific cytokine environment known for inducing inflammation, assessing their potential role in atherosclerosis progression.

摘要

背景

动脉粥样硬化是一种影响动脉的慢性炎症性疾病，与心血管疾病密切相关。以高低密度脂蛋白（LDL）、低高密度脂蛋白（HDL）和血浆甘油三酯升高为特征的血脂异常是一个关键危险因素。当氧化型LDL（ox-LDL）等修饰脂蛋白激活免疫系统时，动脉粥样硬化的发生就开始了。本研究探讨了调节性T细胞（Tregs）和白细胞介素10（IL-10）、6（IL-6）和17（IL-17）在动脉粥样硬化发生中的作用。

方法

从患有稳定型心绞痛（SAP）的医院患者中采集样本。使用Ficoll密度梯度分离外周血单个核细胞（PBMCs），并通过流式细胞术进行分析。使用ELISA测量细胞培养上清液中IL-10、IL-6和IL-17的水平。数据以平均值±标准误表示，并使用统计软件进行分析。

结果

结果表明，只有患者在高剂量ox-LDL治疗后Treg和IL-10水平降低。与未处理的PBMCs相比，在高剂量n-LDL和低/高剂量ox-LDL处理后，NCA组和SA组均观察到IL-6显著降低。

结论与未来方向

未来的研究将探讨n-LDL和ox-LDL在已知诱导炎症的特定细胞因子环境中对Th17/Treg免疫反应的影响，评估它们在动脉粥样硬化进展中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/e8fbda39e007/ms9-86-4456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/cb79105d6716/ms9-86-4456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/2068351eda79/ms9-86-4456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/e8fbda39e007/ms9-86-4456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/cb79105d6716/ms9-86-4456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/2068351eda79/ms9-86-4456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4491/11305802/e8fbda39e007/ms9-86-4456-g003.jpg

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