Didehban Shiva, Jafari Elham, Hosseini Ali, Khorasani Parisa
Department of Pathology, Pathology and Stem Cell Research Center, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran.
Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Pathol. 2024 Spring;19(2):152-159. doi: 10.30699/IJP.2024.2011275.3170. Epub 2024 Jan 29.
BACKGROUND & OBJECTIVE: Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia in adults with various signs, symptoms, and types of progression. In this study, we have investigated the frequency and correlation of laboratory findings including peripheral blood smear, bone marrow aspiration and biopsy, and cellular immunophenotyping in CLL patients.
In this cross-sectional and retrospective study, the laboratory information of all 161 patients with definite diagnoses of CLL was extracted, and the frequency and correlation between different laboratory data were analyzed by descriptive statistics methods and Jamovi software version 2022.
Demographic factors such as age and gender, and laboratory factors such as anemia, thrombocytopenia, white blood cell count, percentage of lymphocytes, and patterns of bone marrow involvement were evaluated for 161 patients. There was a significant relationship between the bone marrow iron storage and the percentage of FMC7 marker expression with the percentage of atypical lymphocytes in the peripheral blood.
Chronic lymphocytic leukemia, a prevalent form of leukemia associated with substantial mortality and morbidity, can be detected through a range of diagnostic techniques. Analyzing the results of these diagnostic tests and examining the prevalence of these indicators in patients afflicted with the condition can prove highly beneficial for prompt disease diagnosis, and prognosis determination among affected individuals.
慢性淋巴细胞白血病（CLL）是成人中最常见的白血病类型之一，具有多种体征、症状和进展类型。在本研究中，我们调查了CLL患者实验室检查结果的频率及相关性，这些检查包括外周血涂片、骨髓穿刺和活检以及细胞免疫表型分析。
在这项横断面回顾性研究中，提取了所有161例确诊为CLL患者的实验室信息，并通过描述性统计方法和Jamovi 2022软件版本分析了不同实验室数据之间的频率及相关性。
对161例患者评估了年龄和性别等人口统计学因素，以及贫血、血小板减少、白细胞计数、淋巴细胞百分比和骨髓受累模式等实验室因素。骨髓铁储存、FMC7标志物表达百分比与外周血非典型淋巴细胞百分比之间存在显著相关性。
慢性淋巴细胞白血病是一种常见的白血病形式，具有较高的死亡率和发病率，可通过一系列诊断技术进行检测。分析这些诊断测试的结果并检查这些指标在患病患者中的流行情况，对于疾病的早期诊断以及受影响个体的预后判断可能非常有益。
