Larue-Achagiotis C, Le Magnen J
Appetite. 1985 Dec;6(4):319-29. doi: 10.1016/s0195-6663(85)80001-5.
The effects of continuous intravenous (i.v.) or intraperitoneal (i.p.) infusion of regular insulin on food intake (FI) and body weight (BW) were examined. When rats were infused i.v. with insulin at 0.2 IU/h for 14 days, BW increased until the 10th day and then plateaued, whereas FI was augmented until the end of treatment. The 24-h hyperphagia was mainly due to a diurnal increase in FI--resulting mainly from a large augmentation in meal number, with unchanged meal size. Nocturnal meal number increased and meal size decreased so that nocturnal FI was not affected. At the cessation of infusion, rats became hypophagic and lost weight. Another group of animals, infused with a lower dose (0.1 IU/h), showed that the increases in BW and FI were dose-dependent. Insulin infused (0.2 IU/h) for 14 days via an i.p. catheter increased FI and BW. The 24-h increase in FI was again mainly due to an enhanced diurnal intake, but at the cessation of insulin infusion rats did not lose BW. In rats infused with insulin at 0.1 IU/h for 14 days, BW and FI did not increase. In rats infused via an implanted minipump with insulin at 0.1 IU/h for 7 days, however, BW increased significantly over controls for the first 3 days, without any significant change in FI, the discrepancy between results observed here and other results is discussed, these effects suggest a relative ineffectiveness of the i.p. route compared to i.v.
研究了持续静脉内（i.v.）或腹腔内（i.p.）输注常规胰岛素对食物摄入量（FI）和体重（BW）的影响。当以0.2 IU/h的速度给大鼠静脉内输注胰岛素14天时，体重在第10天前增加，之后趋于平稳，而食物摄入量在治疗结束前一直增加。24小时的食欲亢进主要是由于白天食物摄入量增加，这主要是由于进餐次数大幅增加，而每餐食量不变。夜间进餐次数增加而每餐食量减少，因此夜间食物摄入量未受影响。输注停止后，大鼠食欲减退并体重减轻。另一组动物以较低剂量（0.1 IU/h）输注胰岛素，结果显示体重和食物摄入量的增加呈剂量依赖性。通过腹腔内导管以0.2 IU/h的速度输注胰岛素14天可增加食物摄入量和体重。24小时食物摄入量的增加同样主要是由于白天摄入量增加，但胰岛素输注停止后大鼠体重并未减轻。以0.1 IU/h的速度给大鼠输注胰岛素14天，体重和食物摄入量并未增加。然而，通过植入式微型泵以0.1 IU/h的速度给大鼠输注胰岛素7天，在前3天体重比对照组显著增加，食物摄入量无任何显著变化，本文观察到的结果与其他结果之间的差异进行了讨论，这些结果表明与静脉内途径相比，腹腔内途径相对无效。
