McGowan M K, Andrews K M, Grossman S P
Committee on Biopsychology, University of Chicago.
Behav Neurosci. 1992 Apr;106(2):380-5. doi: 10.1037//0735-7044.106.2.380.
These experiments examined the extent to which chronic intrahypothalamic (IH) insulin infusions that alter circadian patterns of food intake (FI) affect the regulation of other diurnally varying behavior in the rat. One-week IH insulin infusion (1.5 microU/hr) significantly decreases rats' night FI and increases day FI but does not alter the diurnal pattern of activity. Mean daily core temperature increased slightly but significantly during insulin infusion, the daily peak of the body temperature rhythm did not shift significantly, and the daily range of body temperature increased. IH insulin infusion in rats living in constant light and thus without circadian rhythm of FI led to significant decreases in FI and body weight. These data support the conclusion that IH insulin infusion alters food intake and body weight through a specific effect on a neural system that regulates food intake and body weight, and not by altering circadian rhythms.
这些实验研究了改变食物摄入（FI）昼夜模式的慢性下丘脑内（IH）胰岛素输注在多大程度上影响大鼠其他昼夜变化行为的调节。为期一周的IH胰岛素输注（1.5微单位/小时）显著降低大鼠夜间的食物摄入量，增加白天的食物摄入量，但不改变昼夜活动模式。在胰岛素输注期间，平均每日核心体温略有但显著升高，体温节律的每日峰值没有显著变化，体温的每日波动范围增加。在持续光照下生活且因此没有FI昼夜节律的大鼠中进行IH胰岛素输注，导致食物摄入量和体重显著下降。这些数据支持以下结论：IH胰岛素输注通过对调节食物摄入和体重的神经系统产生特定作用来改变食物摄入和体重，而不是通过改变昼夜节律。
