通过电荷改性过滤器去除内毒素
Endotoxin removal by charge-modified filters.
作者信息
Gerba C P, Hou K
出版信息
Appl Environ Microbiol. 1985 Dec;50(6):1375-7. doi: 10.1128/aem.50.6.1375-1377.1985.
Abstract
The effects of positively charged nylon and depth (cellulose-diatomaceous earth) filters on endotoxin removal from various solutions were evaluated. The charged filter media removed significant amounts of Escherichia coli and natural endotoxin from tap water, distilled water, sugars, and NaCl solutions; no significant removal of endotoxin was observed with negatively charged filter media. The extent of removal was influenced by pH, the presence of salts, and organic matter. Such media may be useful for the control of endotoxins in raw-product water or solutions used to prepare parenteral drug products or in other fluids where endotoxin control is desired.
摘要
评估了带正电荷的尼龙和深层（纤维素 - 硅藻土）过滤器对从各种溶液中去除内毒素的效果。带电荷的过滤介质能从自来水、蒸馏水、糖溶液和氯化钠溶液中去除大量的大肠杆菌和天然内毒素；而带负电荷的过滤介质未观察到对内毒素的显著去除效果。去除程度受pH值、盐的存在以及有机物的影响。此类介质可用于控制用于制备注射用药品的原水或溶液中的内毒素，或用于其他需要控制内毒素的液体中。
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本文引用的文献
1
Properties of binding of Escherichia coli endotoxin to various matrices.大肠杆菌内毒素与各种基质的结合特性。
J Clin Microbiol. 1981 Jan;13(1):49-53. doi: 10.1128/jcm.13.1.49-53.1981.
2
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Appl Environ Microbiol. 1980 Nov;40(5):892-6. doi: 10.1128/aem.40.5.892-896.1980.
3
Production and properties of cyanobacterial endotoxins.蓝藻内毒素的产生与特性
Appl Environ Microbiol. 1982 Jan;43(1):104-9. doi: 10.1128/aem.43.1.104-109.1982.
4
[The use of asbestos filter beds in the production of sterile and pyrogen free solutions].[石棉滤床在无菌无热原溶液生产中的应用]
Pharmazie. 1975 Nov;30(11):752-3.
5
Determination of endotoxins in sugar with the Limulus test.用鲎试剂法测定糖中的内毒素。
Appl Environ Microbiol. 1979 Dec;38(6):1078-80. doi: 10.1128/aem.38.6.1078-1080.1979.
6
Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation.不同聚集状态溶液中内毒素（热原）的过滤去除
Appl Environ Microbiol. 1977 Oct;34(4):382-5. doi: 10.1128/aem.34.4.382-385.1977.
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