Poullard Anna, Charles Sheena
From The University of Texas MD Anderson Cancer Center, Houston, Texas.
J Adv Pract Oncol. 2024 Jan;15(1):56-58. doi: 10.6004/jadpro.2024.15.1.6. Epub 2024 Jan 1.
The primary objectives of early phase clinical trials are to determine the safety, tolerability, and recommended doses of an investigational agent for patients with advanced cancer. Although these advances in cancer treatment have resulted in patients living longer, patients often experience psychological side effects that may affect sexual health and intimacy. It is estimated that cancer and its subsequent treatments affect the sexual health and intimacy of 40% to 100% of this patient population. Patients with advanced cancer who have undergone numerous treatments may be impacted negatively, not only physically (such as being disfigured by surgical resection) but also emotionally in relationship aspects with their intimate partners. Health-care providers who treat patients with advanced cancer enrolled in early phase clinical trials tend to focus primarily on treatment, physical side effects, and symptom management. Advanced practice providers (APPs) are accustomed to performing comprehensive physical examinations on patients; however, research indicates that intimacy and sexuality are most often excluded in discussions with patients with advanced cancer. The purpose of the article is to increase awareness of the need to address intimacy and sexuality in this patient population and to encourage APPs to make this a part of their everyday practice.
早期临床试验的主要目标是确定针对晚期癌症患者的研究药物的安全性、耐受性和推荐剂量。尽管癌症治疗方面的这些进展使患者寿命延长,但患者常常会经历可能影响性健康和亲密关系的心理副作用。据估计,癌症及其后续治疗会影响40%至100%的此类患者群体的性健康和亲密关系。接受过多次治疗的晚期癌症患者可能会受到负面影响,不仅在身体方面(如因手术切除而毁容),而且在与亲密伴侣的关系方面也会受到情感影响。参与早期临床试验的晚期癌症患者的医护人员往往主要关注治疗、身体副作用和症状管理。高级执业医护人员(APPs)习惯于对患者进行全面的身体检查;然而,研究表明,在与晚期癌症患者的讨论中,亲密关系和性问题最常被排除在外。本文的目的是提高人们对在这一患者群体中解决亲密关系和性问题必要性的认识,并鼓励高级执业医护人员将此纳入日常实践。