Naryanan Vignesh, Mahajan Rahul, Ashraf Raihan, Sharma Apoorva, Lal Brij, De Dipankar, Handa Sanjeev
From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clinical Photography, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol. 2024 May-Jun;69(3):238-240. doi: 10.4103/ijd.ijd_1089_23. Epub 2024 Jun 26.
Mosaicism has long been considered the underlying mechanism of segmental infantile hemangiomas (SIH). This was a prospective pilot case-control study conducted with the objective to quantify the percentage overlap of silhouettes of facial SIH with those of Blaschko lines (the most well studied archetypical pattern of mosaicism on face) as compared to other mosaic disorders on face. Lesional silhouettes of 8 patients with SIH (Group A) and 6 patients with other facial dermatosis known to have blaschkoidal distribution (Group B), were overlapped on a standardized template with Blaschkoidal lines on the frontal view of face. The alignment was done via the auto align tool of Photoshop and the percentage of overlap was calculated with an online image comparison software (IMGonline.com.ua). There was a significant difference in mean overlap in Group A (72.92 ± 15.6 %) as compared to Group B (90.1 ± 4.3%; =0.018). Hence, we concluded that facial SIH do not follow lines of Blaschko.
长期以来，镶嵌现象一直被认为是节段性婴儿血管瘤（SIH）的潜在机制。这是一项前瞻性试点病例对照研究，目的是量化面部SIH轮廓与Blaschko线（面部研究最充分的典型镶嵌模式）的重叠百分比，并与面部其他镶嵌性疾病进行比较。8例SIH患者（A组）和6例已知有Blaschko线分布的其他面部皮肤病患者（B组）的病损轮廓，在面部正视图上与带有Blaschko线的标准化模板重叠。通过Photoshop的自动对齐工具进行对齐，并使用在线图像比较软件（IMGonline.com.ua）计算重叠百分比。与B组（90.1±4.3%）相比，A组的平均重叠率有显著差异（72.92±15.6%；P=0.018）。因此，我们得出结论，面部SIH不遵循Blaschko线。
