Ekinci Alper, Kilic Sevilay O, Demir Nesrin, Siddikoglu Duygu
From the Department of Dermatology, Kahramanmaras Necip Fazil City Hospital, Kahramanmaras, Turkiye.
Department of Dermatology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkiye.
Indian J Dermatol. 2024 May-Jun;69(3):232-237. doi: 10.4103/ijd.ijd_470_23. Epub 2024 Jun 26.
Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
The present study aims to evaluate the relationship of these cytokines with rosacea.
A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants.
The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 ± 24.07 pg/ml, 18.46 ± 8.18 pg/ml, and 25.74 ± 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 ± 19.90 pg/ml, 44.61 ± 22.27 pg/ml, and 45.61 ± 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant ( < 0.001).
Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea.
酒渣鼻是一种慢性炎症性皮肤病。先前的研究已确定白细胞介素-36（IL-36）、白细胞介素-37（IL-37）和白细胞介素-38（IL-38）可能在各种炎症性疾病的发病机制中起作用。
本研究旨在评估这些细胞因子与酒渣鼻的关系。
本研究共纳入100人，其中包括50名酒渣鼻患者和50名健康对照者。通过采集所有参与者的血清样本，采用酶联免疫吸附测定（ELISA）法测量IL-36、IL-37和IL-38水平。
患者组中IL-36、IL-37和IL-38的血清平均水平分别为52.17±24.07皮克/毫升、18.46±8.18皮克/毫升和25.74±8.36纳克/升。对照组中IL-36、IL-37和IL-38的血清平均水平分别为32.99±19.90皮克/毫升、44.61±22.27皮克/毫升和45.61±17.32纳克/升。患者组和对照组中IL-36、IL-37和IL-38的血清水平差异具有统计学意义（<0.001）。
基于这些发现，IL-36升高以及IL-37和IL-38降低可能促成酒渣鼻的发病机制。未来酒渣鼻的治疗可以针对酒渣鼻发病机制中的这些可能环节并与之相互作用。
