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托法替布用于治疗激素性酒渣鼻。

Tofacitinib for the Treatment of Steroid-Induced Rosacea.

作者信息

Li Tianhao, Wang Henghong, Wang Caiying, Hao Pingsheng

机构信息

Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2022 Nov 23;15:2519-2521. doi: 10.2147/CCID.S392280. eCollection 2022.

DOI:10.2147/CCID.S392280
PMID:36452437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9701777/
Abstract

PURPOSE

Conventional treatment suffers from a dilemma of poor efficacy. The clinical use of Janus kinase (JAK) inhibitors in the treatment of steroid-induced rosacea has rarely been explored.

PATIENTS AND METHODS

We present a case of steroid-induced rosacea successfully treated with JAK inhibitor tofacitinib, with no adverse effects.

RESULTS

This case report of successful treatment shows a good clinical efficacy of JAK inhibitors tofacitinib in the treatment of SIR.

CONCLUSION

JAK inhibitor tofacitinib may be a promising agent for the treatment with steroid-induced rosacea, especially for patients who have failed to conventional therapy.

摘要

目的

传统治疗存在疗效不佳的困境。Janus激酶(JAK)抑制剂在治疗类固醇诱导的酒渣鼻方面的临床应用鲜有探索。

患者和方法

我们报告一例类固醇诱导的酒渣鼻患者成功使用JAK抑制剂托法替布治疗,且无不良反应。

结果

这例成功治疗的病例报告显示JAK抑制剂托法替布在治疗类固醇诱导的酒渣鼻方面具有良好的临床疗效。

结论

JAK抑制剂托法替布可能是治疗类固醇诱导的酒渣鼻的一种有前景的药物,尤其是对于传统治疗失败的患者。

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本文引用的文献

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Janus kinase inhibitors in dermatology: A systematic review.皮肤科的 Janus 激酶抑制剂:系统评价。
J Am Acad Dermatol. 2017 Apr;76(4):745-753.e19. doi: 10.1016/j.jaad.2016.12.004. Epub 2017 Feb 4.
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STAT1 plays a role in TLR signal transduction and inflammatory responses.信号转导及转录激活因子1(STAT1)在Toll样受体(TLR)信号转导和炎症反应中发挥作用。
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Successful Treatment of Granulomatous Rosacea by JAK Inhibitor Abrocitinib: A Case Report.JAK抑制剂阿布昔替尼成功治疗肉芽肿性酒渣鼻:一例报告
Clin Cosmet Investig Dermatol. 2023 Nov 20;16:3369-3374. doi: 10.2147/CCID.S440138. eCollection 2023.
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JAK1 inhibitor abrocitinib for the treatment of steroid-induced rosacea: case series.JAK1抑制剂阿布昔替尼治疗激素性玫瑰痤疮:病例系列
Front Med (Lausanne). 2023 Sep 1;10:1239869. doi: 10.3389/fmed.2023.1239869. eCollection 2023.
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TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.TLR2 的表达在酒渣鼻中增加,并刺激角质形成细胞产生增强的丝氨酸蛋白酶。
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