Othram Inc., The Woodlands, TX 77381, USA.
Department of Forensic Medicine, University of Helsinki, Finland.
Biotechniques. 2024;76(9):425-431. doi: 10.1080/07366205.2024.2386218. Epub 2024 Aug 9.
Investigative leads are not generated by traditional forensic DNA testing, if the source of the forensic evidence or a 1st degree relative of unidentified human remains is not in the DNA database. In such cases, forensic genetic genealogy (FGG) can provide valuable leads. However, FGG generated genetic data contain private and sensitive information. Therefore, it is essential to deploy approaches that minimize unnecessary disclosure of these data to mitigate potential risks to individual privacy. We recommend protective practices that need not impact effective reporting of relationship identifications. Examples include performing one-to-one comparisons of DNA profiles of third-party samples and evidence samples offline with an "air gap" to the internet and shielding the specific shared single nucleotide polymorphisms (SNP) states and locations by binning adjacent SNPs in forensic reports. Such approaches reduce risk of unwanted access to or reverse engineering of third-party individuals' genetic data and can give these donors greater confidence to support use of their DNA profiles in FGG investigation.
如果法医学证据的来源或身份不明的人类遗骸的一级亲属不在 DNA 数据库中,则不会通过传统法医 DNA 测试生成调查线索。在这种情况下,法医遗传系谱学(FGG)可以提供有价值的线索。然而,FGG 生成的遗传数据包含私人和敏感信息。因此,部署可以最大限度减少这些数据不必要披露的方法来减轻对个人隐私的潜在风险至关重要。我们建议采取保护措施,这些措施不会影响关系识别的有效报告。例如,在离线状态下,通过与互联网之间的“空气间隙”对第三方样本和证据样本的 DNA 图谱进行一对一比较,并在法医报告中通过将相邻的 SNP 分组来屏蔽特定的共享单核苷酸多态性(SNP)状态和位置。这些方法降低了第三方个人遗传数据被非法访问或逆向工程的风险,并且可以使这些供体更有信心支持在 FGG 调查中使用他们的 DNA 图谱。