Department of Forensic Science, Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT 06516, USA.
Genes (Basel). 2022 Aug 1;13(8):1381. doi: 10.3390/genes13081381.
Forensic Genetic Genealogy (FGG) has fast become a popular tool in criminal investigations since it first emerged in 2018. FGG is a novel investigatory tool that has been applied to hundreds of unresolved cold cases in the United States to generate investigative leads and identify unknown individuals. Consumer DNA testing and the public's increased curiosity about their own DNA and genetic ancestry, have greatly contributed to the availability of human genetic data. Genetic genealogy has been a field of study/interest for many years as both amateur and professional genetic genealogists use consumer DNA data to explore genetic connections in family trees. FGG encompasses this knowledge by applying advanced sequencing technologies to forensic DNA evidence samples and by performing genetic genealogy methods and genealogical research, to produce possible identities of unknown perpetrators of violent crimes and unidentified human remains. This combination of forensic genetics, genetic genealogy, and genealogical research has formed a new subdiscipline within the forensic sciences. This paper will summarize the individual disciplines that led to the emergence of FGG, its practice in forensic investigations, and current/future considerations for its use.
法医遗传谱系学(FGG)自 2018 年首次出现以来,迅速成为刑事调查中的热门工具。FGG 是一种新颖的调查工具,已在美国数百起未解决的冷案中应用,以产生调查线索并识别未知个体。消费者 DNA 测试以及公众对自身 DNA 和遗传背景的日益好奇,极大地促进了人类遗传数据的可用性。遗传谱系学多年来一直是一个研究/关注领域,因为业余和专业的遗传谱系学家都使用消费者 DNA 数据来探索家谱中的遗传联系。FGG 通过将先进的测序技术应用于法医 DNA 证据样本,并通过进行遗传谱系学方法和谱系研究,来生成暴力犯罪和身份不明的人类遗骸的未知犯罪者的可能身份,从而涵盖了这方面的知识。法医遗传学、遗传谱系学和谱系研究的结合已经形成了法医学的一个新分支。本文将总结导致 FGG 出现的各个学科,它在法医调查中的实践,以及目前/未来对其使用的考虑。