Department of Urology, University of Verona, Integrate University Hospital, Verona 37126, Italy.
Asian J Androl. 2024 Nov 1;26(6):569-574. doi: 10.4103/aja202443. Epub 2024 Aug 9.
An enduring debate in research revolves around the association between elevated endogenous testosterone levels and prostate cancer. This systematic review is intended to assess the present understanding of the role of endogenous testosterone in the diagnosis and treatment of low- and intermediate-risk prostate cancer. Our search strategy was the following: (endogenous testosterone) AND (((low risk) OR (intermediate risk)) AND ((diagnosis) OR (treatment))) AND (prostate cancer); that was applied to PubMed, Web of Science, and Scopus databases to identify pertinent articles. Two investigators performed an independent selection following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The preliminary investigation detected 105 records, and 81 records remained after eliminating duplicates. Following the review of titles and abstracts, 71 articles were excluded. A comprehensive examination of the full text was conducted for 10 articles, excluding 3 of them. After revising the references of eligible articles, other 3 articles were included. We finally identified 10 suitable studies, including three main topics: (1) association between endogenous testosterone and European Association of Urology (EAU) risk classes; (2) association between endogenous testosterone density and the tumor load; and (3) association of endogenous testosterone with tumor upgrading and tumor upstaging. Actual literature about the impact of endogenous testosterone on low- and intermediate-risk prostate cancer is not numerous, but appears to be still conflicting. More investigations are needed to increase the consistency of the literature's results.
在研究中，一个持久的争论围绕着内源性睾丸酮水平升高与前列腺癌之间的关联。本系统综述旨在评估内源性睾丸酮在诊断和治疗低危和中危前列腺癌中的作用的现有认识。我们的搜索策略如下：（内源性睾丸酮）和（（低危）或（中危））和（（诊断）或（治疗））和（前列腺癌）；这被应用于 PubMed、Web of Science 和 Scopus 数据库以识别相关文章。两名调查员按照系统评价和荟萃分析的首选报告项目（PRISMA）指南独立进行选择。初步调查发现了 105 条记录，消除重复后仍有 81 条记录。在审查标题和摘要后，排除了 71 篇文章。对 10 篇全文进行了全面检查，排除了其中的 3 篇。在修订了合格文章的参考文献后，又纳入了其他 3 篇文章。我们最终确定了 10 项合适的研究，包括三个主要主题：（1）内源性睾丸酮与欧洲泌尿外科学会（EAU）风险分类之间的关系；（2）内源性睾丸酮密度与肿瘤负荷之间的关系；（3）内源性睾丸酮与肿瘤升级和肿瘤分期升级之间的关系。关于内源性睾丸酮对低危和中危前列腺癌影响的实际文献并不多，但似乎仍然存在争议。需要进行更多的研究来提高文献结果的一致性。
