Jardillier J C, Desoize B, Delvincourt C
Bull Cancer. 1985;72(6):519-26.
The first data on acidic phosphatase were published in the beginning of the 20th century. The applications to prostatic carcinoma were performed by Gutman in 1936. The enzyme is a glycoprotein which action mechanism is similar to a histidine-phosphatase. Acidic phosphatase has been found in numerous tissues and blood-stream cells. Its structure is dimeric and glycans average 10% of the M.W. The enzyme has been assayed in serum, using numerous substrates in the presence of specific inhibitors. The best results were obtained with thymolphthalein phosphate. Improvements were done by assays in bone marrow and by the introduction of immunological technics which lead to a better appreciation of tumoral invasion.
关于酸性磷酸酶的首批数据于20世纪初发表。1936年古特曼将其应用于前列腺癌。该酶是一种糖蛋白，其作用机制类似于组氨酸磷酸酶。酸性磷酸酶已在众多组织和血流细胞中被发现。其结构为二聚体，聚糖平均占分子量的10%。在血清中对该酶进行检测时，在特定抑制剂存在的情况下使用了多种底物。使用磷酸麝香草酚酞可获得最佳结果。通过骨髓检测以及引入免疫技术进行了改进，这使得对肿瘤侵袭有了更好的评估。
