Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Cells. 2024 Jul 26;13(15):1263. doi: 10.3390/cells13151263.
Canine cutaneous histiocytoma (CCH) represents a significant proportion of dog skin tumours, often manifesting as the most common neoplastic skin condition in young animals. Predominantly affecting dogs under four, these tumours appear primarily as solitary lesions that may regress spontaneously. This study, conducted over five years at the University of Trás-os-Montes e Alto Douro, involved a detailed histopathological and ultrastructural examination of 93 CCH cases. Histologically, these tumours showed distinct patterns of lymphoid infiltration, which contributed to their classification into four groups based on the inflammatory response and histological architecture. Most tumours displayed signs of epidermal invasion and frequent mitotic figures, with necrosis present in over half of the cases. Ultrastructurally, the neoplastic cells were characterised by pleomorphism, abundant organelles, and adherens-type junctions. This study offers significant insights into the pathophysiology and morphological characteristics of CCH, underscoring the importance of detailed histological and ultrastructural analysis in accurately diagnosing and understanding this common canine tumour.
犬皮肤组织细胞瘤（CCH）是犬皮肤肿瘤的重要组成部分，常表现为年轻动物中最常见的肿瘤性皮肤疾病。这些肿瘤主要影响四岁以下的犬，通常表现为单一的病变，可能会自发消退。本研究在特拉斯-奥斯-蒙蒂斯-埃奥多大学进行了五年，对 93 例 CCH 病例进行了详细的组织病理学和超微结构检查。组织学上，这些肿瘤显示出明显的淋巴细胞浸润模式，根据炎症反应和组织学结构将其分为四组。大多数肿瘤显示出表皮浸润和频繁有丝分裂的迹象，超过一半的病例有坏死。超微结构上，肿瘤细胞表现出多形性、丰富的细胞器和黏附连接。本研究深入了解了 CCH 的病理生理学和形态学特征，强调了详细的组织学和超微结构分析在准确诊断和理解这种常见的犬肿瘤中的重要性。
