火鸡红细胞被动血凝试验作为受伤人员破伤风特异性预防的指导方法。
Turkey red blood cell passive haemagglutination assay as guideline for specific prevention of tetanus in injured persons.
作者信息
Bistoni F, Marconi P, Perito S, Bastianini L, Antenucci R, Pitzurra M
出版信息
Bull World Health Organ. 1985;63(5):905-14.
Turkey red blood cell passive haemagglutination assays (TRBC-HA) were carried out on serum samples from 873 injured patients in order to compare individual prophylactic treatment against tetanus based on the anti-tetanus antibody levels with interventions based on anamnestic criteria. The results showed a great difference: according to the anamnesis 124 persons (14.2%) were protected, 253 (29%) were partially protected, and 496 (56.8%) were unprotected; according to the TRBC-HA assay, 479 (54.9%) were protected, 279 (32%) partially protected, and 115 (13.2%) unprotected.The efficiency of the prophylactic treatments given on the basis of the two criteria was also compared in a study of 129 injured patients who were divided in two groups: group 1 (50 patients) received 250 IU of human tetanus immunoglobulin (HTI) regardless of their tetanus immunity, and group II (79 patients) received appropriate or no treatment depending on the level of anti-tetanus antibodies determined by TRBC-HA assay. The results showed that prophylactic interventions based on the anti-tetanus antibody levels can give protection in 100% of injured patients at minimum cost and risk.
为了比较根据抗破伤风抗体水平进行的个体破伤风预防治疗与基于既往史标准的干预措施，对873名受伤患者的血清样本进行了火鸡红细胞被动血凝试验（TRBC-HA）。结果显示出很大差异：根据既往史，124人（14.2%）受到保护，253人（29%）部分受到保护，496人（56.8%）未受保护；根据TRBC-HA检测，479人（54.9%）受到保护，279人（32%）部分受到保护，115人（13.2%）未受保护。在一项针对129名受伤患者的研究中，还比较了基于这两个标准进行的预防性治疗的效果，这些患者被分为两组：第一组（50名患者）无论其破伤风免疫情况如何，均接受250 IU人破伤风免疫球蛋白（HTI），第二组（79名患者）根据TRBC-HA检测确定的抗破伤风抗体水平接受适当治疗或不治疗。结果表明，基于抗破伤风抗体水平的预防性干预措施能够以最低的成本和风险为100%的受伤患者提供保护。
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