Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara, Turkey.
Faculty of Sciences, Department of Chemistry, Cankırı Karatekin University, Cankırı, Turkey.
Mikrochim Acta. 2024 Aug 9;191(9):527. doi: 10.1007/s00604-024-06605-9.
A sophisticated electrochemical sensor is presented employing a glassy carbon electrode (GCE) modified with a novel composite of synthesized graphitic carbon nitride (g-CN) and CoNiO bimetallic oxide nanoparticles (g-CN/CoNiO). The sensor's electrocatalytic capabilities for Sunitinib (SUNI) oxidation were demonstrated exceptional performance with a calculated detection limit (LOD) of 52.0 nM. The successful synthesis and integrity of the composite were confirmed through meticulous characterization using various techniques. FT-IR analysis affirmed the successful synthesis of g-CN/CoNiO by providing insights into its molecular structure. XRD, FE-SEM, SEM-EDX, and BET analyses collectively validated the material's structural integrity, surface morphology, and electrocatalytic performance. Optimization of key analytical parameters, such as loading volume, concentration, electrolyte solution type, and pH, enhanced the electrocatalytic sensing capabilities of g-CN/CoNiO. The synergistic interaction between g-CN and CoNiO bimetallic oxide nanoparticles executed the sensor highly effective in the electrical oxidation of SUNI. Across a concentration range of 0.1-83.8 µM SUNI, the anodic peak current exhibited a linear increase with good precision. Application of the newly developed g-CN/CoNiO system to detect SUNI in a variety of samples, including urine, human serum, and capsule dosage forms, obtained satisfactory recoveries ranging from 97.1 to 103.0%. This methodology offers a novel approach to underscore the potential of the developed sensor for applications in biological and pharmaceutical monitoring.
一种采用玻璃碳电极（GCE）修饰的新型石墨相氮化碳（g-CN）和 CoNiO 双金属氧化物纳米粒子（g-CN/CoNiO）复合材料的电化学传感器被提出。该传感器对舒尼替尼（SUNI）氧化具有优异的电催化性能，计算出的检测限（LOD）为 52.0 nM。通过各种技术的仔细表征，确认了复合材料的成功合成和完整性。FT-IR 分析通过提供其分子结构的见解，证实了 g-CN/CoNiO 的成功合成。XRD、FE-SEM、SEM-EDX 和 BET 分析共同验证了材料的结构完整性、表面形态和电催化性能。优化关键分析参数，如负载量、浓度、电解质溶液类型和 pH 值，提高了 g-CN/CoNiO 的电催化传感性能。g-CN 和 CoNiO 双金属氧化物纳米粒子之间的协同相互作用使传感器在 SUNI 的电氧化中具有很高的效率。在 0.1-83.8 µM 的 SUNI 浓度范围内，阳极峰电流表现出线性增加，具有良好的精度。将新开发的 g-CN/CoNiO 系统应用于多种样品中 SUNI 的检测，包括尿液、人血清和胶囊剂型，获得了令人满意的回收率，范围为 97.1-103.0%。该方法为开发的传感器在生物和药物监测中的应用提供了一种新的方法。
