Torchi B, Villani U, Bruni G, Lavezzari M, Mandelli V
Int J Clin Pharmacol Res. 1983;3(3):167-73.
Recent reports imply that the prostaglandin system is involved in the pathogenesis of pain due to renal colic, and prostaglandin-synthetase inhibitors have been proposed in the management of this condition. A dose-response study has therefore been performed in patients with renal colic, using two intravenous non-steroidal antiinflammatory drugs, indoprofen and lysine acetylsalicylate (ASA). Seventy-five inpatients (15 per group) were treated with three dose levels of indoprofen (100, 200 and 400 mg) or two dose levels of ASA (500 and 1500 mg) according to a double-blind, randomized, parallel-group design. The patients scored their pain at 15, 30, 60, 120 and 180 minutes after treatment; they also assessed the overall efficacy of treatment by means of a visual analogue scale. The results showed that, in terms of mean pain score, there was a prompt analgesic response in each treatment group, higher effects being obtained with increasing dose levels of both drugs. However, the statistical prerequisites for calculating a potency ratio between the drugs under study were satisfied only for a few variables, in which cases the relative potency of indoprofen to ASA varied between 7.1 and 8.8. The analysis of the frequencies of response, on the other hand, revealed for indoprofen a significant dose-effect regression, the higher dose of this drug giving a complete or nearly complete relief of pain in the majority of patients.
近期报告表明，前列腺素系统参与了肾绞痛所致疼痛的发病机制，因此有人提出用前列腺素合成酶抑制剂来治疗这种疾病。为此，对肾绞痛患者进行了一项剂量反应研究，使用了两种静脉注射的非甾体抗炎药，即吲哚洛芬和赖氨酸乙酰水杨酸（ASA）。根据双盲、随机、平行组设计，75名住院患者（每组15人）接受了三个剂量水平的吲哚洛芬（100、200和400毫克）或两个剂量水平的ASA（500和1500毫克）治疗。患者在治疗后15、30、60、120和180分钟对疼痛进行评分；他们还通过视觉模拟量表评估了治疗的总体疗效。结果表明，就平均疼痛评分而言，每个治疗组均有迅速的镇痛反应，两种药物剂量增加时效果更佳。然而，仅在少数变量中满足计算所研究药物之间效价比的统计前提条件，在这些情况下，吲哚洛芬相对于ASA的相对效价在7.1至8.8之间变化。另一方面，对反应频率的分析显示，吲哚洛芬有显著的剂量效应回归，该药物的较高剂量在大多数患者中能使疼痛完全或几乎完全缓解。
