Lima Débora Machado de, Santos Anna Lívia Oliveira, Melo Matheus Reis Santos de, Tavares Denise Crispim, Martins Carlos Henrique Gomes, Sousa Raquel Maria Ferreira
Chemistry Instituto, Federal University of Uberlândia, Av. João Naves de Ávila 2121, Uberlândia 38400-902, MG, Brazil.
Institute of Biomedical Sciences, Federal University of Uberlândia, Av. João Naves de Ávila 2121, Uberlândia 38400-902, MG, Brazil.
Plants (Basel). 2024 Jul 23;13(15):2011. doi: 10.3390/plants13152011.
The study evaluated the preservative potential of Pohl. leaf extracts in cosmetics, highlighting their antioxidant, antimicrobial, and in vitro cytotoxic activities for ethanolic extract prepared by the maceration and tincture method. Total phenol content showed a higher phenol concentration in ethanolic extract and tinctures, and by LC-MS/MS-ESI-QTOF analysis, flavonoids, hydrolyzed tannins, and phenolic acids were identified. The ethanolic extract and tincture showed high antimicrobial activity against , , and (MIC < 50 µg mL), high antioxidant activity (EC < 50 µg mL in the DPPH method, and results > 450 µmol trolox equivalent in the ABTS and FRAP method), and low cytotoxicity in human keratinocytes (IC > 350 µg mL). The results suggest these extracts could be an alternative to synthetic preservatives in the cosmetic industry.
该研究评估了[植物名称]叶提取物在化妆品中的防腐潜力，重点突出了其通过浸渍法和酊剂法制备的乙醇提取物的抗氧化、抗菌和体外细胞毒性活性。总酚含量表明乙醇提取物和酊剂中的酚浓度较高，通过液相色谱-串联质谱-电喷雾电离-四极杆飞行时间质谱（LC-MS/MS-ESI-QTOF）分析，鉴定出了黄酮类化合物、水解单宁和酚酸。乙醇提取物和酊剂对[具体微生物名称1]、[具体微生物名称2]和[具体微生物名称3]表现出高抗菌活性（最低抑菌浓度<50μg/mL），高抗氧化活性（在二苯基苦味酰基自由基（DPPH）法中EC<50μg/mL，在2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）和铁还原抗氧化能力（FRAP）法中结果>450μmol Trolox当量），并且在人角质形成细胞中细胞毒性较低（半数抑制浓度>350μg/mL）。结果表明，这些提取物可作为化妆品行业中合成防腐剂的替代品。
