American University of the Caribbean, Saint Martin.
Department of Dermatology, Columbia University Medical Center, New York, NY.
Dermatitis. 2019 Jan/Feb;30(1):32-45. doi: 10.1097/DER.0000000000000428.
Parabens now being formally declared as the American Contact Dermatitis Society (non)allergen of the year, the allergologic concerns regarding parabens raised during the past century are no longer a significant issue. The more recent toxicological concerns regarding parabens are more imposing, stemming from the gravity of the noncutaneous adverse health effects for which they have been scrutinized for the past 20 years. These include endocrine activity, carcinogenesis, infertility, spermatogenesis, adipogenesis, perinatal exposure impact, and nonallergologic cutaneous, psychologic, and ecologic effects. To assert that parabens are safe for use as currently used in the cosmetics, food, and pharmaceutical industries, all toxicological end points must be addressed. We seek to achieve perspective through this exercise: perspective for the professional assessing systemic risk of parabens by all routes of exposure. The data reviewed in this article strive to provide a balanced perspective for the consumer hopefully to allay concerns regarding the safety of parabens and facilitate an informed decision-making process. Based on currently available scientific information, claims that parabens are involved in the genesis or propagation of these controversial and important health problems are premature. Haste to remove parabens from consumer products could result in their substitution with alternative, less proven, and potentially unsafe alternatives, especially given the compelling data supporting the lack of significant dermal toxicity of this important group of preservatives.
由于对羟基苯甲酸酯现在被正式宣布为美国接触性皮炎学会（非）过敏原年度物质，过去一个世纪以来对其过敏的担忧已不再是一个重要问题。最近对其毒理学的担忧更加突出，这源于过去 20 年来对其进行了严格审查的非皮肤不良健康影响的严重性。这些影响包括内分泌活动、致癌作用、不育、精子发生、脂肪生成、围产期暴露影响以及非过敏皮肤、心理和生态影响。为了声称对羟基苯甲酸酯在化妆品、食品和制药行业中的当前使用是安全的，必须解决所有毒理学终点问题。我们希望通过这种做法获得一种视角：通过所有暴露途径评估对羟基苯甲酸酯全身风险的专业人员的视角。本文综述的数据旨在为消费者提供一个平衡的视角，希望减轻对其安全性的担忧，并促进知情决策过程。基于目前可用的科学信息，声称对羟基苯甲酸酯参与这些有争议和重要健康问题的发生或传播还为时过早。仓促将对羟基苯甲酸酯从消费品中去除可能会导致用替代物替代，而替代物的效果则不太明显，而且潜在的安全性也较差，尤其是因为有令人信服的数据支持该重要防腐剂组缺乏明显的皮肤毒性。
