Percin Alper, Ozden Ali Veysel, Yenisehir Semiha, Pehlivanoglu Berkay Eren, Yılmaz Ramazan Cihad
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Avrasya University, 61080 Trabzon, Turkey.
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bahcesehir University, 34330 Istanbul, Turkey.
J Clin Med. 2024 Jul 26;13(15):4385. doi: 10.3390/jcm13154385.
Transcutaneous auricular vagus nerve stimulation (TaVNS) is a non-invasive method of electrical stimulation used to autonomic neuromodulation. Position and form of the electrodes are important for the effectiveness of autonomic modulation. This study was aimed to investigate the effect of TaVNS in-ear and behind-ear on autonomic variables. : A total of 76 healthy participants (male: 40, female: 36) were randomized into four groups as in-ear TaVNS, behind-ear TaVNS, in-ear sham, and behind-ear sham. The TaVNS protocol included bilateral auricular stimulation for 20 min, 25 hertz frequency, a pulse width of 250 μs, and a suprathreshold current (0.13-50 mA). Heart rate (HR), systolic and diastolic blood pressure (SBP and DBP), and heart rate variability (HRV) were measured baseline and after stimulation. The parameters RMSSD (root mean square of consecutive differences between normal heartbeats), LF power (low-frequency), and HF power (high-frequency) were assessed in the HRV analysis. : HR decreased in the in-ear TaVNS after intervention ( < 0.05), but did not change in behind-ear TaVNS and sham groups compared to baseline ( > 0.05). SBP and DBP decreased and RMSSD increased in the in-ear and behind-ear TaVNS groups ( < 0.05), but did not change in sham groups compared to baseline ( > 0.05). There was no significant difference in LF and HF power after TaVNS compared to baseline in all groups ( > 0.05). SBP was lower and RMSSD was higher in-ear TaVNS than behind-ear TaVNS after intervention ( < 0.05). : In-ear TaVNS appears to be more effective than behind-ear TaVNS in modulating SBP and RMSSD, but this needs to be studied in larger populations.
经皮耳迷走神经刺激（TaVNS）是一种用于自主神经调节的非侵入性电刺激方法。电极的位置和形式对自主调节的有效性很重要。本研究旨在探讨耳内和耳后TaVNS对自主变量的影响。：总共76名健康参与者（男性40名，女性36名）被随机分为四组，即耳内TaVNS组、耳后TaVNS组、耳内假刺激组和耳后假刺激组。TaVNS方案包括双侧耳部刺激20分钟，频率25赫兹，脉冲宽度250微秒，以及阈上电流（0.13 - 50毫安）。在刺激前和刺激后测量心率（HR）、收缩压和舒张压（SBP和DBP）以及心率变异性（HRV）。在HRV分析中评估参数RMSSD（正常心跳之间连续差值的均方根）、低频功率（LF功率）和高频功率（HF功率）。：干预后耳内TaVNS组的HR下降（<0.05），但与基线相比，耳后TaVNS组和假刺激组无变化（>0.05）。耳内和耳后TaVNS组的SBP和DBP下降，RMSSD增加（<0.05），但与基线相比，假刺激组无变化（>0.05）。与基线相比，所有组TaVNS后LF和HF功率均无显著差异（>0.05）。干预后，耳内TaVNS组的SBP低于耳后TaVNS组，RMSSD高于耳后TaVNS组（<0.05）。：耳内TaVNS在调节SBP和RMSSD方面似乎比耳后TaVNS更有效，但这需要在更大规模的人群中进行研究。
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