State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, China.
Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin, China.
PLoS One. 2022 Feb 10;17(2):e0263833. doi: 10.1371/journal.pone.0263833. eCollection 2022.
Transcutaneous auricular vagus nerve stimulation (taVNS) has shown positive effects on a variety of diseases. Considering that decreased heart rate variability (HRV) is closely associated with morbidity and mortality for a variety of diseases, it is important to investigate the effect of taVNS on HRV. In Study 1, we conducted a two-stage cross-over trial to compare the effects of taVNS and sham taVNS (staVNS) on HRV. In Study 2, we systematically tested the effects of different taVNS parameters on high frequency (HF) component of HRV. The results showed that taVNS significantly increased measurements of root mean square of the difference between successive RR intervals (RMSSD), percentage of number of pairs of adjacent RR intervals differing greater than 50ms (pRR50), standard deviation of all RR intervals (SDRR), HF. Significantly, enhancement of HF and pRR50 persisted into recovery period. In addition, higher baseline LF/HF ratio was associated with greater LF/HF ratio decrease. Findings also showed that there was no significant difference in measurements of HF between different taVNS parameters. These studies suggest that taVNS could increase HRV, it may help taVNS in the treatment of low HRV related diseases. However, taVNS may not have parameter-specific effects on HRV.
经皮耳迷走神经刺激（taVNS）已被证明对多种疾病具有积极作用。鉴于心率变异性（HRV）降低与多种疾病的发病率和死亡率密切相关，因此研究 taVNS 对 HRV 的影响非常重要。在研究 1 中，我们进行了一项两阶段交叉试验，比较 taVNS 和假刺激 taVNS（staVNS）对 HRV 的影响。在研究 2 中，我们系统地测试了不同 taVNS 参数对 HRV 高频（HF）成分的影响。结果表明，taVNS 显著增加了 RR 间期差值均方根（RMSSD）、RR 间期差值大于 50ms 的相邻对数（pRR50）、所有 RR 间期标准差（SDRR）、HF 的测量值。值得注意的是，HF 和 pRR50 的增强持续到恢复期。此外，较高的基线 LF/HF 比值与 LF/HF 比值的降低幅度更大相关。研究结果还表明，不同 taVNS 参数之间的 HF 测量值没有显著差异。这些研究表明，taVNS 可以增加 HRV，它可能有助于 taVNS 治疗与 HRV 降低相关的疾病。然而，taVNS 对 HRV 可能没有特定参数的影响。
