Rackov Sanja, Pilić Branka, Janković Nenad, Kosanić Marijana, Petković Marijana, Vraneš Milan
Faculty of Technology Novi Sad, Department of Materials Engineering, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.
Institute for Information Technologies Kragujevac, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Polymers (Basel). 2024 Jul 23;16(15):2094. doi: 10.3390/polym16152094.
Herein, we report an efficient and facile strategy for the preparation of imidazolium-based ionic liquid (IL) monomers ([CVIm][Br], = 2, 4, 6, 8, 10, and 12) and their corresponding polymeric ionic liquids (PILs) with potent antimicrobial activities against Gram-negative and Gram-positive bacteria and fungi. The electrospinning technique was utilized to tailor the polymers with the highest antimicrobial potency into porous membranes that can be easily implemented into diverse systems and extend their practical bactericidal application. The antimicrobial mechanism of obtained ILs, polymers, and nanomaterials is considered concerning the bearing chain length, polymerization process, and applied processing technique that provides a unique fibrous structure. The structure composition was selected due to the well-established inherent amphiphilicity that 1-alkylimidazolium ILs possess, coupled with proven antimicrobial, antiseptic, and antifungal behavior. The customizable nature of ILs and PILs complemented with electrospinning is exploited for the development of innovative antimicrobial performances born from the intrinsic polymer itself, offering solutions to the increasing challenge of bacterial resistance. This study opens up new prospects toward designer membranes providing a complete route in their designing and revolutionizing the approach of fabricating multi-functional systems with tunable physicochemical, surface properties, and interesting morphology.
在此，我们报道了一种高效且简便的策略，用于制备基于咪唑鎓的离子液体（IL）单体（[CVIm][Br]， = 2、4、6、8、10和12）及其相应的具有针对革兰氏阴性菌、革兰氏阳性菌和真菌的强效抗菌活性的聚合离子液体（PIL）。利用静电纺丝技术将具有最高抗菌效力的聚合物制成多孔膜，这些膜可轻松应用于各种系统，并扩展其实际杀菌应用。考虑到支链长度、聚合过程以及提供独特纤维结构的应用加工技术，对所得离子液体、聚合物和纳米材料的抗菌机制进行了研究。由于1-烷基咪唑鎓离子液体具有公认的固有两亲性，以及已证实的抗菌、防腐和抗真菌性能，因此选择了这种结构组成。离子液体和聚合离子液体的可定制性质与静电纺丝相结合，被用于开发源自内在聚合物本身的创新抗菌性能，为日益严峻的细菌耐药性挑战提供解决方案。这项研究为设计膜开辟了新的前景，为其设计提供了完整的途径，并彻底改变了制造具有可调物理化学、表面性质和有趣形态的多功能系统的方法。
