Maurice and Gabriela Goldschleger Eye Research Institute, Faculty of Medicine and Health Sciences, Sheba Medical Center, Tel Aviv University, Ramat-Gan 5262000, Israel.
Int J Mol Sci. 2024 Aug 2;25(15):8444. doi: 10.3390/ijms25158444.
is an opportunistic pathogen that causes severe infections in compromised hosts. infections are difficult to treat because of the inherent ability of the bacteria to develop antibiotic resistance, secrete a variety of virulence factors, and form biofilms. The secreted aminopeptidase (PaAP) is an emerging virulence factor, key in providing essential low molecular weight nutrients and a cardinal modulator of biofilm development. PaAP is therefore a new potential target for therapy of infections. The present review summarizes the current knowledge of PaAP, with special emphasis on its biochemical and enzymatic properties, activation mechanism, biological roles, regulation, and structure. Recently developed specific inhibitors and their potential as adjuncts in the treatment of infections are also described.
是一种机会性病原体，可导致机体免疫功能低下者发生严重感染。由于细菌固有产生抗生素耐药性、分泌多种毒力因子并形成生物膜的能力， 感染的治疗较为困难。分泌的氨肽酶（PaAP）是一种新兴的毒力因子，为提供必需的低分子量营养物质和生物膜形成的主要调节剂。因此，PaAP 是 感染治疗的新潜在靶点。本文综述了 PaAP 的最新研究进展，特别强调了其生化和酶学特性、激活机制、生物学作用、调控和结构。还描述了最近开发的特异性抑制剂及其作为 感染辅助治疗的潜在应用。
