School of Biomolecular and Biomedical Sciences, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland.
Int J Mol Sci. 2021 Mar 18;22(6):3128. doi: 10.3390/ijms22063128.
is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating evolution and its interactions with the host throughout the course of infection.
是囊性纤维化 (CF) 患者的主要病原体，导致发病率和死亡率上升。它极强的适应能力极大地促进了其引发慢性感染的能力。病原体的适应性和灵活性得益于其拥有大量的毒力因子，使其能够针对环境中的不同胁迫因素做出相应的反应。深入了解这些毒力机制对于设计针对这种多耐药病原体的治疗策略和疫苗至关重要。因此，本综述描述了 的主要毒力因子，以及它在 CF 呼吸道等恶劣环境中生存所经历的适应过程。庞大的 基因组（5 到 7MB）极大地促进了其适应能力；因此，基因组研究为阐明 的进化及其在感染过程中与宿主的相互作用提供了重要的见解。
