Nutrition and Toxicology Division, Food Technology Department, Federal Institute of Industrial Research Oshodi, Lagos, Nigeria.
Department of Biology and Environmental Science, School of Science and Technology, Sefako Makgatho Health Science University, Pretoria, 0208, South Africa.
Inflammopharmacology. 2024 Oct;32(5):3099-3108. doi: 10.1007/s10787-024-01538-4. Epub 2024 Aug 10.
Apigenin is a flavone-kind of flavonoid present in fruits and vegetables. Apigenin exhibits biological activities including neuropharmacological effects against different neurological disorders. In this study, we summarize and discuss the molecular mechanisms of the anti-neuroinflammatory effects of apigenin in neurological disorders. A systematic review was conducted by searching Google Scholar, Web of Science, Scopus and PubMed. A total of 461 records were retrieved from the search. After screening of the records based on the inclusion criteria, 16 articles were selected and discussed in this study. The results from the selected studies showed that apigenin exhibited anti-neuroinflammatory effect in preclinical studies. The anti-neuroinflammatory mechanisms exhibited by apigenin include inhibition of overproduction of pro-inflammatory cytokines, attenuation of microglia activation via reduction of CD-11b-positive cells, inhibition of ROCK-1 expression and upregulation of miR-15a, p-ERK1/2, p-CREB, and BDNF, downregulation of NLRP3 inflammasome, iNOS and COX-2 expression, reduction of Toll-like receptor-4 expression and inhibition of nuclear factor-kappa B (NF-kB) activation. Overall, apigenin inhibited neuroinflammation which suggests it confers neuroprotective effect against neuronal degeneration in some neurodegenerative conditions. This review provides important neuropharmacological information on the neuroprotective mechanisms of apigenin against neuroinflammation which may be useful for future preclinical and clinical studies.
芹菜素是一种存在于水果和蔬菜中的类黄酮类黄酮。芹菜素有多种生物活性，包括对多种神经障碍的神经药理学作用。在这项研究中，我们总结和讨论了芹菜素在神经障碍中抗神经炎症作用的分子机制。通过在 Google Scholar、Web of Science、Scopus 和 PubMed 上进行系统检索，进行了综述。从搜索中检索到了 461 条记录。根据纳入标准筛选记录后，选择了 16 篇文章进行讨论。所选研究的结果表明，芹菜素在临床前研究中表现出抗神经炎症作用。芹菜素表现出的抗神经炎症机制包括抑制促炎细胞因子的过度产生、通过减少 CD-11b 阳性细胞来减弱小胶质细胞的激活、抑制 ROCK-1 表达和上调 miR-15a、p-ERK1/2、p-CREB 和 BDNF、下调 NLRP3 炎性体、iNOS 和 COX-2 的表达、减少 Toll 样受体-4 的表达和抑制核因子-kappa B (NF-kB) 的激活。总的来说，芹菜素抑制了神经炎症，这表明它对一些神经退行性疾病中的神经元变性具有神经保护作用。该综述提供了关于芹菜素对抗神经炎症的神经保护机制的重要神经药理学信息，这可能对未来的临床前和临床研究有用。
