一种二价Delta/BA.5 mRNA疫苗可引发针对包括JN.1在内的各种SARS-CoV-2谱系的广泛免疫反应。
A bivalent Delta/BA.5 mRNA vaccine elicits broad immune responses against various lineages of SARS-CoV-2 including JN.1.
作者信息
Li Kangyin, Liu Qi, Wu Yan, Wu Bihao, Chen Shaohong, Zhang Xinghai, Jia Xiaoying, Gong Rui, Peng Yucai, Zhang Huajun, Chiu Sandra
机构信息
Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430062, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Liverna Therapeutics Inc., Zhuhai, 519000, China.
出版信息
Virol Sin. 2024 Oct;39(5):833-835. doi: 10.1016/j.virs.2024.08.003. Epub 2024 Aug 8.
• A bivalent Delta/BA.5 mRNA vaccine provides protection against BA.5 in K18-ACE2 mice. • The vaccine protects hamsters from both Delta and BA.5 infections. • The animal immune sera neutralizes various lineages of variants including JN.1.
• 一种二价Delta/BA.5 mRNA疫苗可在K18-ACE2小鼠中提供针对BA.5的保护。
• 该疫苗可保护仓鼠免受Delta和BA.5感染。
• 动物免疫血清可中和包括JN.1在内的各种谱系变体。
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