Health Organisation, Policy and Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Williamson Building, Oxford Road, Manchester, M13 9PL, UK.
BMC Public Health. 2024 Aug 10;24(1):2166. doi: 10.1186/s12889-024-19571-x.
Early detection of intermediate hyperglycaemia, otherwise known as non-diabetic hyperglycaemia (NDH) is crucial to identify people at high risk of developing type 2 diabetes mellitus (T2DM) who could benefit from preventative interventions. Failure to identify NDH may also increase the risks of T2DM-related complications at the time of T2DM diagnosis. We investigate sociodemographic inequalities in identification of NDH in England.
We used nationwide data from the English National Health Service (NHS) National Diabetes Audit, which includes all people who were newly identified with NDH (N = 469,910) or diagnosed with T2DM (N = 222,795) between 1st April 2019 and 31st March 2020. We used regression models to explore inequalities in the under identification of NDH by area-level deprivation and age group.
Of those with a new T2DM diagnosis, 67.3% had no previous record of NDH. The odds of no previous NDH being recorded were higher amongst people living in more deprived areas (Odds ratio (OR) 1.15 (95% confidence intervals (CI) [1.12, 1.19]) most deprived (Q1) compared to least deprived (Q5) quintile) and younger individuals (OR 4.02 (95% CI [3.79, 4.27] under 35s compared to age 75-84)). Deprivation-related inequalities persisted after stratification by age group, with the largest inequalities amongst middle and older age groups. People living in more deprived areas and younger people also had shorter recorded NDH duration before progression to T2DM, and higher T2DM severity at the time of diagnosis.
There is under identification of NDH relative to diagnosis of T2DM amongst people living in more deprived areas and particularly amongst younger people, resulting in missed opportunities for targeted T2DM prevention efforts and potentially contributing to inequalities in T2DM prevalence and severity. More active NDH case-finding amongst these groups may be an important first step in helping to reduce inequalities in T2DM.
早期发现中间高血糖,也称为非糖尿病性高血糖(NDH),对于识别患有 2 型糖尿病(T2DM)风险较高的人群至关重要,这些人可能受益于预防干预措施。未能识别 NDH 也可能会增加 T2DM 相关并发症的风险,尤其是在诊断 T2DM 时。我们研究了英格兰在识别 NDH 方面的社会人口不平等现象。
我们使用了来自英国国家卫生服务(NHS)国家糖尿病审计的全国性数据,其中包括在 2019 年 4 月 1 日至 2020 年 3 月 31 日期间新诊断为 NDH(N=469910)或 T2DM(N=222795)的所有人。我们使用回归模型探讨了按地区贫困程度和年龄组划分的 NDH 识别不足的不平等现象。
在新诊断为 T2DM 的人群中,有 67.3%的人没有以前记录的 NDH。与最贫困(Q1)相比,处于较贫困地区(优势比(OR)1.15(95%置信区间(CI)[1.12, 1.19])的人群记录 NDH 的可能性更高(最贫困(Q1)与最不贫困(Q5)五分位)和年轻个体(OR 4.02(95%CI [3.79, 4.27] 35 岁以下人群与 75-84 岁人群))。在按年龄组分层后,贫困相关的不平等现象仍然存在,在中年和老年群体中差距最大。处于较贫困地区和年轻人群的人在进展为 T2DM 之前记录的 NDH 持续时间更短,并且在诊断时 T2DM 的严重程度更高。
在较贫困地区和特别是在年轻人群中,与 T2DM 诊断相比,NDH 的识别不足,导致错失了有针对性的 T2DM 预防措施的机会,可能导致 T2DM 的患病率和严重程度不平等。在这些人群中更积极地发现 NDH 可能是减少 T2DM 不平等的重要第一步。