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英国国家医疗服务体系糖尿病预防计划对英格兰2型糖尿病发病率的人群水平影响:一项观察性研究。

Population level impact of the NHS Diabetes Prevention Programme on incidence of type 2 diabetes in England: An observational study.

作者信息

McManus Emma, Meacock Rachel, Parkinson Beth, Sutton Matt

机构信息

Division of Population Health, Health Organisation, Policy and Economics, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Suite 12, Floor 7, Williamson Building, Oxford Road, Manchester M13 9PL, United Kingdom.

出版信息

Lancet Reg Health Eur. 2022 May 29;19:100420. doi: 10.1016/j.lanepe.2022.100420. eCollection 2022 Aug.

Abstract

BACKGROUND

The NHS Diabetes Prevention Programme (DPP) is the first nationwide type 2 diabetes prevention programme targeting people with prediabetes. It was rolled out across England from 2016 in three waves. We evaluate the population level impact of the NHS DPP on incidence rates of type 2 diabetes.

METHODS

We use data from the National Diabetes Audit, which records all individuals across England who have been diagnosed with type 2 diabetes by 2019. We use difference-in-differences regression models to estimate the impact of the phased introduction of the DPP on type 2 diabetes incidence. We compare patients registered with the 3,282 general practices enrolled from 2016 (wave 1) and the 1,610 practices enrolled from 2017 (wave 2) to those registered with the 1,584 practices enrolled from 2018 (final wave).

FINDINGS

Incidence rates of type 2 diabetes in wave 1 practices in 2018 and 2019 were significantly lower than would have been expected in the absence of the DPP (difference-in-differences Incident Rate Ratio (IRR) = 0·938 (95% CI 0·905 to 0·972)). Incidence rates were also significantly lower than expected for wave 2 practices in 2019 (difference-in-differences IRR = 0·927 (95% CI 0·885 to 0·972)). These results remained consistent across several robustness checks.

INTERPRETATION

Introduction of the NHS DPP reduced population incidence of type 2 diabetes. Longer follow-up is required to explore whether these effects are maintained or if diabetes onset is delayed.

FUNDING

This research was funded by the National Institute for Health and Care Research (Health Services and Delivery Research, 16/48/07 - Evaluating the NHS Diabetes Prevention Programme (NHS DPP): the DIPLOMA research programme (Diabetes Prevention - Long Term Multimethod Assessment)). The views and opinions expressed in this manuscript are those of the authors and do not necessarily reflect those of the NHS, the National Institute for Health and Care Research or the Department of Health and Social Care.

摘要

背景

英国国家医疗服务体系糖尿病预防项目(DPP)是首个针对糖尿病前期人群的全国性2型糖尿病预防项目。该项目于2016年分三批在英格兰全面推行。我们评估了英国国家医疗服务体系糖尿病预防项目对2型糖尿病发病率的人群层面影响。

方法

我们使用了来自国家糖尿病审计的数据,该数据记录了截至2019年英格兰所有被诊断为2型糖尿病的个体。我们使用双重差分回归模型来估计分阶段引入糖尿病预防项目对2型糖尿病发病率的影响。我们将2016年(第一批)登记的3282家全科诊所的患者以及2017年(第二批)登记的1610家诊所的患者与2018年(最后一批)登记的1584家诊所的患者进行比较。

研究结果

2018年和2019年第一批诊所的2型糖尿病发病率显著低于在没有糖尿病预防项目情况下的预期发病率(双重差分发病率比(IRR)=0.938(95%置信区间0.905至0.972))。2019年第二批诊所的发病率也显著低于预期(双重差分IRR =0.927(95%置信区间0.885至0.972))。这些结果在多项稳健性检验中保持一致。

解读

英国国家医疗服务体系糖尿病预防项目的引入降低了人群中2型糖尿病的发病率。需要更长时间的随访来探究这些效果是否能持续,或者糖尿病发病是否会延迟。

资金来源

本研究由国家卫生与保健研究所资助(卫生服务与交付研究,16/48/07 - 评估英国国家医疗服务体系糖尿病预防项目(NHS DPP):文凭研究项目(糖尿病预防 - 长期多方法评估))。本手稿中表达的观点和意见仅代表作者,不一定反映英国国家医疗服务体系、国家卫生与保健研究所或卫生与社会保健部的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4adb/9160476/dffaec0acfcb/gr1.jpg

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