Doğan Selin, Koç Taha Yasin, Karadayı Mehmet
Institute of Natural and Applied Sciences, Atatürk University, Erzurum, Turkey.
Department of Biology, Atatürk University Faculty of Science, Erzurum, Turkey.
Eurasian J Med. 2023 Dec;55(1):165-169. doi: 10.5152/eurasianjmed.2023.23393.
Intestinal microbiota, which plays an important role in human health by interacting with each other or with its hosts, is afected by many endogenous and exogenous factors. Any change in the composition and functionality of the intestinal microbiota, both in number and diversity, causes disruption of intestinal functioning and paves the way for many diseases. In this regard, many antimicrobial peptides, especially bacteriocins, synthesized by lactic acid bacteria are thought to be natural resources with a high potential for the protection of the intestinal microbiota and the treatment of intestinal diseases. Both the intestinal microbiota itself and many foodborne bacteria produce bacteriocins that can inhibit pathogenic microorganisms that cause serious health problems and regulate the intestinal microbiota. This review aims to provide a comprehensive overview of the intestinal microbiota, the properties of lactic acid bacteria, their bacteriocins, and the efects of bacteriocins on the human health.
肠道微生物群通过相互作用或与宿主相互作用在人类健康中发挥重要作用，它受到许多内源性和外源性因素的影响。肠道微生物群在组成和功能上的任何变化，无论是数量还是多样性方面，都会导致肠道功能紊乱，并为许多疾病埋下隐患。在这方面，许多由乳酸菌合成的抗菌肽，尤其是细菌素，被认为是保护肠道微生物群和治疗肠道疾病的极具潜力的天然资源。肠道微生物群本身以及许多食源细菌都会产生细菌素，这些细菌素可以抑制导致严重健康问题的致病微生物，并调节肠道微生物群。这篇综述旨在全面概述肠道微生物群、乳酸菌的特性、它们产生的细菌素以及细菌素对人类健康的影响。
