• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IIb类细菌素植物乳杆菌素NC8调节不同肠型的肠道微生物群

A Class IIb Bacteriocin Plantaricin NC8 Modulates Gut Microbiota of Different Enterotypes .

作者信息

Pu Jiaqian, Hang Shuting, Liu Manman, Chen Ziqi, Xiong Jiayi, Li Yongquan, Wu Hongchen, Zhao Xiaodan, Liu Shuxun, Gu Qing, Li Ping

机构信息

Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

出版信息

Front Nutr. 2022 Jun 30;9:877948. doi: 10.3389/fnut.2022.877948. eCollection 2022.

DOI:10.3389/fnut.2022.877948
PMID:35845772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9280423/
Abstract

The gut microbiota is engaged in multiple interactions affecting host health. Bacteriocins showed the ability of impeding the growth of intestinal pathogenic bacteria and modulating gut microbiota in animals. Few studies have also discovered their regulation on human intestinal flora using an simulated system. However, little is known about their effect on gut microbiota of different enterotypes of human. This work evaluated the modification of the gut microbiota of two enterotypes (ET B and ET P) by the class IIb bacteriocin plantaricin NC8 (PLNC8) by using an fermentation model of the intestine. Gas chromatography results revealed that PLNC8 had no influence on the gut microbiota's production of short-chain fatty acids in the subjects' samples. PLNC8 lowered the Shannon index of ET B' gut microbiota and the Simpson index of ET P' gut microbiota, according to 16S rDNA sequencing. In ET B, PLNC8 enhanced the abundance of , , , , , and while decreasing the abundance of . _9, , , , and were found more abundant in ET P. The current study adds to our understanding of the impact of PLNC8 on the human gut microbiota and lays the groundwork for future research into PLNC8's effects on human intestinal disease.

摘要

肠道微生物群参与多种影响宿主健康的相互作用。细菌素显示出在动物体内抑制肠道病原菌生长和调节肠道微生物群的能力。也有少数研究使用模拟系统发现了它们对人类肠道菌群的调节作用。然而，关于它们对不同人类肠型肠道微生物群的影响知之甚少。这项工作通过使用肠道发酵模型，评估了IIb类细菌素植物乳杆菌素NC8（PLNC8）对两种肠型（ET B和ET P）肠道微生物群的改变。气相色谱结果显示，PLNC8对受试者样本中肠道微生物群产生短链脂肪酸没有影响。根据16S rDNA测序，PLNC8降低了ET B肠道微生物群的香农指数和ET P肠道微生物群的辛普森指数。在ET B中，PLNC8增加了[具体菌种1]、[具体菌种2]、[具体菌种3]、[具体菌种4]、[具体菌种5]和[具体菌种6]的丰度，同时降低了[具体菌种7]的丰度。在ET P中发现[具体菌种8]、[具体菌种9]、[具体菌种10]、[具体菌种11]和[具体菌种12]更为丰富。本研究增加了我们对PLNC8对人类肠道微生物群影响的理解，并为未来研究PLNC8对人类肠道疾病的影响奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/49d946f7a40a/fnut-09-877948-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/aca2ad79e60f/fnut-09-877948-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/5d171fd838b3/fnut-09-877948-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/7f242717b844/fnut-09-877948-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/be0689ac77cd/fnut-09-877948-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/13831874ced6/fnut-09-877948-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/49d946f7a40a/fnut-09-877948-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/aca2ad79e60f/fnut-09-877948-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/5d171fd838b3/fnut-09-877948-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/7f242717b844/fnut-09-877948-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/be0689ac77cd/fnut-09-877948-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/13831874ced6/fnut-09-877948-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d6/9280423/49d946f7a40a/fnut-09-877948-g006.jpg

相似文献

1
A Class IIb Bacteriocin Plantaricin NC8 Modulates Gut Microbiota of Different Enterotypes .IIb类细菌素植物乳杆菌素NC8调节不同肠型的肠道微生物群
Front Nutr. 2022 Jun 30;9:877948. doi: 10.3389/fnut.2022.877948. eCollection 2022.
2
Production of plantaricin NC8 by Lactobacillus plantarum NC8 is induced in the presence of different types of gram-positive bacteria.植物乳杆菌NC8在不同类型革兰氏阳性菌存在的情况下会诱导产生植物乳杆菌素NC8。
Arch Microbiol. 2004 Jan;181(1):8-16. doi: 10.1007/s00203-003-0606-8. Epub 2003 Nov 29.
3
Induction of plantaricin production in Lactobacillus plantarum NC8 after coculture with specific gram-positive bacteria is mediated by an autoinduction mechanism.植物乳杆菌NC8与特定革兰氏阳性菌共培养后，其植物乳杆菌素的产生是由一种自诱导机制介导的。
J Bacteriol. 2004 Mar;186(5):1556-64. doi: 10.1128/JB.186.5.1556-1564.2004.
4
Diversity and enterotype in gut bacterial community of adults in Taiwan.台湾成年人肠道细菌群落的多样性与肠型
BMC Genomics. 2017 Jan 25;18(Suppl 1):932. doi: 10.1186/s12864-016-3261-6.
5
Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis.乳酸杆菌和细菌素PLNC8αβ对牙周病原体牙龈卟啉单胞菌的抗菌作用。
BMC Microbiol. 2016 Aug 18;16(1):188. doi: 10.1186/s12866-016-0810-8.
6
subsp. BB-12 Has Effect Against Obesity by Regulating Gut Microbiota in Two Phases in Human Microbiota-Associated Rats.亚种BB - 12通过在人类微生物群相关大鼠中两阶段调节肠道微生物群对肥胖具有作用。
Front Nutr. 2022 Jan 10;8:811619. doi: 10.3389/fnut.2021.811619. eCollection 2021.
7
Gut Microbiota Alterations and Their Functional Differences in Depression According to Enterotypes in Asian Individuals.亚洲人群根据肠型的不同，其抑郁症中肠道微生物群的改变及其功能差异。
Int J Mol Sci. 2023 Aug 28;24(17):13329. doi: 10.3390/ijms241713329.
8
Gut microbiota profile in healthy Indonesians.健康印度尼西亚人的肠道微生物群特征。
World J Gastroenterol. 2019 Mar 28;25(12):1478-1491. doi: 10.3748/wjg.v25.i12.1478.
9
A Korean-Style Balanced Diet Has a Potential Connection with Enterotype and Reduction of Metabolic Syndrome Incidence in Korean Adults.韩式平衡饮食可能与肠型有关，并降低韩国成年人代谢综合征的发病率。
Nutrients. 2021 Feb 3;13(2):495. doi: 10.3390/nu13020495.
10
Plantaricin NC8 from Lactobacillus plantarum causes cell membrane disruption to Micrococcus luteus without targeting lipid II.植物乳杆菌 NC8 素通过破坏细胞膜而不是靶向脂质 II 来杀伤藤黄微球菌。
Appl Microbiol Biotechnol. 2018 Sep;102(17):7465-7473. doi: 10.1007/s00253-018-9182-3. Epub 2018 Jul 7.

引用本文的文献

1
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis.肠道微生物群衍生的短链脂肪酸充当肠-肝-脑轴的介质。
Metab Brain Dis. 2025 Feb 8;40(2):122. doi: 10.1007/s11011-025-01554-5.
2
The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health.乳酸菌产生的细菌素及其在促进胃肠道健康方面的应用前景
Foods. 2024 Dec 2;13(23):3887. doi: 10.3390/foods13233887.
3
Lactobacillaceae differentially impact butyrate-producing gut microbiota to drive CNS autoimmunity.

本文引用的文献

1
Probiotic Potential of a Folate-Producing Strain LZ217 and Its Modulation Effects on Human Gut Microbiota.产叶酸菌株LZ217的益生菌潜力及其对人体肠道微生物群的调节作用。
Foods. 2022 Jan 16;11(2):234. doi: 10.3390/foods11020234.
2
sp. nov., a novel butyrate-producing bacteria isolated from faeces of a patient with Crohn's disease.一株新的丁酸盐产生菌，从一名克罗恩病患者的粪便中分离得到。
Int J Syst Evol Microbiol. 2021 Dec;71(12). doi: 10.1099/ijsem.0.005129.
3
Effects of Nisin, Cecropin, and Pursh on the Intestinal Microbiome of Common Carp ().
乳杆菌科通过差异化影响丁酸产生菌肠道微生物群，从而驱动中枢神经系统自身免疫。
Gut Microbes. 2024 Jan-Dec;16(1):2418415. doi: 10.1080/19490976.2024.2418415. Epub 2024 Oct 27.
4
Effect of Bacteriocins on the Intestinal Microbiota.细菌素对肠道微生物群的影响。
Eurasian J Med. 2023 Dec;55(1):165-169. doi: 10.5152/eurasianjmed.2023.23393.
5
Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques.噬菌体裂解酶用于肠道微生物组调节：当前的挑战和使能技术。
Gut Microbes. 2024 Jan-Dec;16(1):2387144. doi: 10.1080/19490976.2024.2387144. Epub 2024 Aug 6.
6
Bacteriocins: potentials and prospects in health and agrifood systems.细菌素：健康与农业食品系统中的潜力与前景
Arch Microbiol. 2024 Apr 25;206(5):233. doi: 10.1007/s00203-024-03948-y.
7
Modulation of the Gut Microbiota by the Plantaricin-Producing D13, Analysed in the DSS-Induced Colitis Mouse Model.植物乳杆菌 D13 通过调控肠道微生物群缓解 DSS 诱导的结肠炎。
Int J Mol Sci. 2023 Oct 18;24(20):15322. doi: 10.3390/ijms242015322.
8
Purification and characterization of bacteriocin produced by a strain of ZFM216.ZFM216菌株产生的细菌素的纯化与特性分析
Front Microbiol. 2022 Nov 10;13:1050807. doi: 10.3389/fmicb.2022.1050807. eCollection 2022.
乳酸链球菌素、天蚕素和普尔什对鲤鱼肠道微生物群的影响（）。
Front Nutr. 2021 Oct 21;8:729437. doi: 10.3389/fnut.2021.729437. eCollection 2021.
4
Impact of nisin on Clostridioides difficile and microbiota composition in a faecal fermentation model of the human colon.乳酸链球菌素对艰难梭菌和人结肠粪便发酵模型中微生物群落组成的影响。
J Appl Microbiol. 2022 Feb;132(2):1397-1408. doi: 10.1111/jam.15250. Epub 2021 Aug 26.
5
Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury.综述：肠道微生物群及其代谢产物短链脂肪酸对放射性肠损伤的影响。
Front Cell Infect Microbiol. 2021 Jul 9;11:577236. doi: 10.3389/fcimb.2021.577236. eCollection 2021.
6
: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health.: 一种具有新兴抗微生物耐药性的有趣的耐气肠道厌氧菌，在人类健康中具有致病性和益生菌作用。
Gut Microbes. 2021 Jan-Dec;13(1):1922241. doi: 10.1080/19490976.2021.1922241.
7
Plantaricin NC8 αβ prevents Staphylococcus aureus-mediated cytotoxicity and inflammatory responses of human keratinocytes.植物乳杆菌素 NC8αβ 可预防金黄色葡萄球菌介导的人角质形成细胞的细胞毒性和炎症反应。
Sci Rep. 2021 Jun 15;11(1):12514. doi: 10.1038/s41598-021-91682-6.
8
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome.生酮饮食通过改变肠道微生物组减少结肠 3 组固有淋巴细胞从而缓解结肠炎。
Signal Transduct Target Ther. 2021 Apr 23;6(1):154. doi: 10.1038/s41392-021-00549-9.
9
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?短链脂肪酸及其产生菌：IBD 的一种被忽视的治疗方法？
EBioMedicine. 2021 Apr;66:103293. doi: 10.1016/j.ebiom.2021.103293. Epub 2021 Apr 1.
10
Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism.山楂多糖通过调节肠道微生物群和 SCFAs 代谢缓解结肠炎。
Int J Biol Macromol. 2021 Jun 30;181:357-368. doi: 10.1016/j.ijbiomac.2021.03.137. Epub 2021 Mar 24.