Zhou Bo, Qu Xia, Li Minjun, Wang Xi, Xu Qi, Wang Jianhong, Liu Xiaoli, Zhang Lili, Zhang Ting, Gu Jialu, Zhou Lijun, Peng Nan, Niu Wenquan, Wang Lin
Child Healthcare Center, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Endocrine. 2025 Jan;87(1):304-313. doi: 10.1007/s12020-024-03988-w. Epub 2024 Aug 11.
The aim of this study was to observe the influence of differential nutritional status on bone age (BA) change according to body mass index (BMI) and analyze the risk of advanced bone age in children with overweight and obesity.
In total 23,305 children from Beijing were included in this cross-sectional study. Childhood overweight and obesity were defined according to the China and World Health Organization growth criteria. The data were analyzed by the R coding platform version 4.3.0.
Under the Chinese criteria, 29%, 15%, and 4% of boys with overweight; 33%, 33%, and 3% of boys with obesity; 39%, 25%, and 2% of girls with overweight; and 37%, 42% and 1% of girls with obesity had advanced, significantly advanced and delayed BA, respectively. After adjustment, overweight (odds ratio, 95% confidence interval, P under the Chinese criteria: 2.52, 2.30-2.75, <0.001 and 4.54, 4.06-5.09, <0.001) and obesity (4.31, 3.85-4.82, <0.001 and 14.01, 12.39-15.85, <0.001) were risk factors for both advanced BA and significantly advanced BA.
Different nutritional statuses lead to differences in children's BA development. Children with overweight and obesity have higher rates of advanced BA under two growth criteria, and girls have more advances in BA than boys do. Overweight and obesity are risk factors for advanced BA.
本研究旨在观察根据体重指数（BMI）划分的不同营养状况对骨龄（BA）变化的影响，并分析超重和肥胖儿童骨龄提前的风险。
本横断面研究共纳入了来自北京的23305名儿童。根据中国和世界卫生组织的生长标准定义儿童超重和肥胖。数据通过R编码平台版本4.3.0进行分析。
按照中国标准，超重男孩中分别有29%、15%和4%骨龄提前、显著提前和延迟；肥胖男孩中分别有33%、33%和3%；超重女孩中分别有39%、25%和2%；肥胖女孩中分别有37%、42%和1%。调整后，超重（比值比，95%置信区间，中国标准下的P值：2.52，2.30 - 2.75，<0.001和4.54，4.06 - 5.09，<0.001）和肥胖（4.31，3.85 - 4.82，<0.001和14.01，12.39 - 15.85，<0.001）是骨龄提前和显著提前的危险因素。
不同的营养状况导致儿童骨龄发育存在差异。在两种生长标准下，超重和肥胖儿童骨龄提前的发生率更高，且女孩骨龄提前的情况比男孩更多。超重和肥胖是骨龄提前的危险因素。
