Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, China; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Neurotherapeutics. 2024 Sep;21(5):e00430. doi: 10.1016/j.neurot.2024.e00430. Epub 2024 Aug 10.
While guidelines recommend 150 min of moderate to vigorous physical activity (MVPA) weekly to enhance health, it remains unclear whether concentrating these activities into 1-2 days of the week, "weekend warrior" (WW) pattern, has the same benefit for neurodegenerative diseases (NDDs). This study aimed to evaluate the associations of WW pattern and the risk of NDDs. This prospective study was conducted using accelerometer-based physical activity data for a full week from June 2013 to December 2015 in the UK Biobank. These individuals were categorized into distinct physical activity patterns, including the WW pattern (i.e., over 50% or 75% of recommended MVPA achieved over 1-2 days), regular pattern, and inactive pattern. Cox proportional hazards model was used to evaluate the association between physical activity patterns and outcomes. Compared to inactive group, WW pattern and regular pattern was similarly linked to a reduced risk of all-cause dementia (WW: Hazard Ratio [HR]: 0.68, 95% Confidence Interval [CI]: 0.56-0.84; regular: HR: 0.86, 95% CI: 0.67-1.1) and all-cause Parkinsonism (WW: HR: 0.47, 95% CI: 0.35-0.63; regular: HR: 0.69, 95% CI: 0.5-0.95). When the exercise threshold was increased to 75% of MVPA, both patterns still were associated with decreased risk of incident all-cause dementia (WW: HR: 0.61, 95% CI: 0.41-0.91; regular: HR: 0.76, 95% CI: 0.63-0.92) and all-cause Parkinsonism (WW: HR: 0.22, 95% CI: 0.10-0.47; regular: HR: 0.59, 95% CI: 0.46-0.75). Concentrating recommended physical activities into 1-2 days per week is associated with a lower incidence of NDDs.
虽然指南建议每周进行 150 分钟的适度到剧烈的身体活动（MVPA）以促进健康，但尚不清楚将这些活动集中在一周中的 1-2 天内，即“周末战士”（WW）模式，是否对神经退行性疾病（NDDs）有相同的益处。本研究旨在评估 WW 模式与 NDDs 风险之间的关联。这项前瞻性研究使用了 2013 年 6 月至 2015 年 12 月在英国生物银行（UK Biobank）进行的为期一周的基于加速度计的身体活动数据。这些个体被分为不同的身体活动模式，包括 WW 模式（即超过 50%或 75%的推荐 MVPA 在 1-2 天内完成）、常规模式和不活动模式。Cox 比例风险模型用于评估身体活动模式与结局之间的关联。与不活动组相比，WW 模式和常规模式与全因痴呆（WW：风险比 [HR]：0.68，95%置信区间 [CI]：0.56-0.84；常规：HR：0.86，95% CI：0.67-1.1）和全因帕金森病（WW：HR：0.47，95% CI：0.35-0.63；常规：HR：0.69，95% CI：0.5-0.95）的风险降低相关。当运动阈值增加到 MVPA 的 75%时，两种模式仍然与全因痴呆（WW：HR：0.61，95% CI：0.41-0.91；常规：HR：0.76，95% CI：0.63-0.92）和全因帕金森病（WW：HR：0.22，95% CI：0.10-0.47；常规：HR：0.59，95% CI：0.46-0.75）的发病率降低相关。将推荐的身体活动集中在每周 1-2 天内与较低的 NDDs 发病率相关。
