Lin Fabin, Lin Yixiang, Chen Lina, Huang Tingting, Lin Tianxin, He Jiarui, Lu Xiaoyang, Chen Xiaochun, Wang Yingqing, Ye Qinyong, Cai Guoen
Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
NPJ Digit Med. 2024 May 23;7(1):137. doi: 10.1038/s41746-024-01135-3.
Increasing evidence suggests an association between exercise duration and Parkinson's disease. However, no high-quality prospective evidence exists confirming whether differences exist between the two modes of exercise, weekend warrior and equal distribution of exercise duration, and Parkinson's risk. Hence, this study aimed to explore the association between different exercise patterns and Parkinson's risk using exercise data from the UK Biobank. The study analyzed data from 89,400 UK Biobank participants without Parkinson's disease. Exercise data were collected using the Axivity AX3 wrist-worn triaxial accelerometer. Participants were categorized into three groups: inactive, regularly active, and engaged in the weekend warrior (WW) pattern. The relationship between these exercise patterns and Parkinson's risk was assessed using a multifactorial Cox model. During a mean follow-up of 12.32 years, 329 individuals developed Parkinson's disease. In a multifactorial Cox model, using the World Health Organization-recommended threshold of 150 min of moderate-to-vigorous physical activity per week, both the active WW group [hazard ratio (HR) = 0.58; 95% confidence interval (CI) = 0.43-0.78; P < 0.001] and the active regular group (HR = 0.44; 95% CI = 0.34-0.57; P < 0.001) exhibited a lower risk of developing Parkinson's disease compared with the inactive group. Further, no statistically significant difference was observed between the active WW and the active regular groups (HR = 0.77; 95% CI = 0.56-1.05; P = 0.099). In conclusion, in this cohort study, both the WW exercise pattern and an equal distribution of exercise hours were equally effective in reducing Parkinson's risk.
越来越多的证据表明运动时长与帕金森病之间存在关联。然而，尚无高质量的前瞻性证据证实周末战士式运动和运动时长均匀分布这两种运动模式之间是否存在差异以及与帕金森病风险的关系。因此，本研究旨在利用英国生物银行的运动数据探索不同运动模式与帕金森病风险之间的关联。该研究分析了89400名无帕金森病的英国生物银行参与者的数据。运动数据通过Axivity AX3腕戴式三轴加速度计收集。参与者被分为三组：不运动组、经常运动组和周末战士（WW）模式组。使用多因素Cox模型评估这些运动模式与帕金森病风险之间的关系。在平均12.32年的随访期间，有329人患上了帕金森病。在多因素Cox模型中，采用世界卫生组织推荐的每周150分钟中等至剧烈身体活动的阈值，与不运动组相比，积极的WW组[风险比（HR）=0.58；95%置信区间（CI）=0.43 - 0.78；P<0.001]和积极的常规运动组（HR = 0.44；95% CI = 0.34 - 0.57；P<0.001）患帕金森病的风险较低。此外，在积极的WW组和积极的常规运动组之间未观察到统计学上的显著差异（HR = 0.77；95% CI = 0.56 - 1.05；P = 0.099）。总之，在这项队列研究中，WW运动模式和运动时长均匀分布在降低帕金森病风险方面同样有效。
