Department of Pathology, Univeristy of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Surg Pathol Clin. 2024 Sep;17(3):359-369. doi: 10.1016/j.path.2024.04.004. Epub 2024 May 30.
The discovery of multiple novel biomarkers in head and neck tumors has led to an increasing interest in utilizing head and neck cytology material as the primary specimens for testing diagnostic and prognostic biomarkers. Although human papillomavirus and programmed death ligand 1 are the most well-established biomarkers tested in cytology specimens, their utilization in cytology is limited by the absence of standardized protocols for specimen collection and fixation. This has led to a quest for innovative techniques to explore the genomic landscape in head and neck tumors and its application in cytology.
头颈部肿瘤中多种新型生物标志物的发现，使得人们越来越有兴趣将头颈部细胞学材料作为检测诊断和预后生物标志物的主要标本。虽然人乳头瘤病毒和程序性死亡配体 1 是在细胞学标本中检测到的最成熟的生物标志物，但由于缺乏标准化的标本采集和固定方案，它们在细胞学中的应用受到限制。这导致人们寻求创新技术来探索头颈部肿瘤的基因组图谱及其在细胞学中的应用。
