Madsen P, Hansen E
Scand J Gastroenterol. 1985 Dec;20(10):1217-20. doi: 10.3109/00365528509089279.
Seventeen patients with chronic pancreatitis and dilated pancreatic ducts were randomly allocated to coeliac plexus block or pancreaticogastrostomy. The number of patients with pain relief after coeliac plexus block and pancreaticogastrostomy did not differ at discharge. Pain score and use of analgesics before coeliac plexus block and 6 months later were unaffected but were significantly less after pancreaticogastrostomy. Operation decreased pancreatic tissue pressure significantly. This pressure decrease is believed to explain pain relief.
17例慢性胰腺炎伴胰管扩张患者被随机分配接受腹腔神经丛阻滞或胰胃吻合术。出院时，腹腔神经丛阻滞组和胰胃吻合术组疼痛缓解的患者数量无差异。腹腔神经丛阻滞前及6个月后的疼痛评分和镇痛药使用情况未受影响，但胰胃吻合术后显著降低。手术显著降低了胰腺组织压力。据信这种压力降低解释了疼痛缓解的原因。
