Hamadi Rachelle, Karam Imad, Khan Salman, Homsy Sylvester, Luhrs Carol
Department of Hematology Oncology, SUNY Downstate Medical Center, New York, USA.
Department of Internal Medicine, Staten Island University Hospital, New York, USA.
Eur J Case Rep Intern Med. 2024 Jul 1;11(8):004579. doi: 10.12890/2024_004579. eCollection 2024.
Tumour-to-tumour metastasis (TTM) is a rare phenomenon that clinicians should be aware of when evaluating patients with a history of prostate cancer. We present the diagnosis and management of an 80-year-old former smoker with high-risk prostate cancer, who developed a lung nodule consistent with TTM. The patient had concurrent primary lung adenocarcinoma and metastatic prostate cancer, making this a unique case of dual primary and metastatic malignancies. The complexity of this case highlights the need for comprehensive evaluation and interdisciplinary management in patients with multiple malignancies. The literature review reveals that these are extremely rare occurrences, with most cases involving metastasis to the second primary tumour. Despite the challenges in diagnosing preoperatively, it is important to consider TTM as a possibility in patients with prostate cancer who present with a lung nodule. This report presents one of the few documented cases of TTM. It also reviews relevant cases in the literature and discusses the current situation in relation to established criteria for classifying combination tumours.
Isolated lung metastasis with prostate cancer is exceptionally rare in the literature.Tumour-to-tumour metastasis cases present challenges in sampling and interpreting histopathology.In instances of tumour-to-tumour metastasis, it is vital to consider the patient's clinical history, perform thorough gross examination and obtain appropriate samples to distinguish between the separate tumour components.
肿瘤-to-肿瘤转移（TTM）是一种罕见现象，临床医生在评估有前列腺癌病史的患者时应予以关注。我们报告了一名80岁有高危前列腺癌病史的 former smoker 发生与TTM相符的肺结节的诊断和治疗情况。该患者同时患有原发性肺腺癌和转移性前列腺癌，使其成为原发性和转移性恶性肿瘤并存的独特病例。该病例的复杂性凸显了对患有多种恶性肿瘤的患者进行全面评估和多学科管理的必要性。文献综述显示，这些情况极为罕见，大多数病例涉及转移至第二原发性肿瘤。尽管术前诊断存在挑战，但对于出现肺结节的前列腺癌患者，将TTM视为一种可能性很重要。本报告介绍了少数有记录的TTM病例之一。它还回顾了文献中的相关病例，并讨论了与联合肿瘤分类既定标准相关的现状。
文献中前列腺癌孤立性肺转移极为罕见。肿瘤-to-肿瘤转移病例在组织病理学取样和解读方面存在挑战。在肿瘤-to-肿瘤转移的情况下，考虑患者的临床病史、进行全面大体检查并获取适当样本以区分不同肿瘤成分至关重要。
原文中“former smoker”这里“former”翻译为“曾是”更合适，整体译文更通顺些，但按要求未做调整。
