Milani Ilaria, Gaita Chiara, Guarisco Gloria, Chinucci Marianna, Parisella Roberta, Piroli Silvia, Bruno Eleonora, Martellucci Annunziata, De Falco Elena, Ricci Fabio, Calogero Antonella, Leonetti Frida, Capoccia Danila
Department of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Breast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Obes Sci Pract. 2024 Aug 9;10(4):e786. doi: 10.1002/osp4.786. eCollection 2024 Aug.
Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC.
Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D.
Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight ( < 0.001). The presence of overweight/obesity and T2D seemed to be associated with a higher incidence of metastasis, recurrence, and triple-negative breast cancer (TNBC) subtype ( < 0.001). Excess body weight was also associated with high histologic grade (G3) ( < 0.005).
These results confirm excess body weight and T2D as unfavorable prognostic factors in terms of the presence of the TNBC subtype, tumor metastasis, recurrence, and aggressiveness (G3 and Ki-67 > 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.
2型糖尿病（T2D）是女性乳腺癌（FBC）的一个危险因素。肥胖也与FBC相关，这也取决于绝经状态。本研究旨在评估肥胖和T2D对FBC发生、侵袭性和浸润性的影响。
收集了335例FBC女性的人口统计学、临床和组织病理学数据，并根据体重类别（102例体重正常、117例超重和116例肥胖）以及是否存在T2D进行分析。
肿瘤诊断时的年龄在体重方面无统计学显著差异；超重或肥胖的女性在绝经后被诊断出患癌的可能性高于体重正常者（<0.001）。超重/肥胖和T2D的存在似乎与转移、复发和三阴性乳腺癌（TNBC）亚型的发生率较高相关（<0.001）。超重还与高组织学分级（G3）相关（<0.005）。
这些结果证实，就TNBC亚型的存在、肿瘤转移、复发和侵袭性（G3和Ki-67>20%）而言，超重和T2D是不良预后因素。本研究强调了对所有女性进行预防的重要性，包括早期筛查和适当的营养计划。
