Montatore Manuela, Zagaria Antonio, Masino Federica, Fascia Giacomo, Debitonto Michele, Guglielmi Giuseppe
Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, Foggia, Foggia, FG 71121 Italy.
Department of Intensive Care and Anaesthesiology, "Dimiccoli" Hospital, Viale Ippocrate 15, Barletta, BT 70051 Italy.
Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3570-3575. doi: 10.1007/s12070-024-04615-w. Epub 2024 Apr 2.
This clinical case presents an unusual case of Lemierre's syndrome (LS) in a young woman of 38-year-old. She arrived in the Emergency Department with a high fever and pharyngology resistant to antibiotic therapy with clarithromycin, ceftriaxone, and cortisone for two weeks. At the blood sampling, there is a marked leucocytosis, and the advice of the otolaryngologist is required given the strong pain in the throat. Due to the tonsillar abscess, a neck CT with a contrast medium is necessary for the otolaryngologist's opinion. The CT shows thrombosis of the jugular vein and left subclavian, with thickening of soft perivascular tissues; these findings suggest Lemierre's syndrome: a septic thrombophlebitis of the jugular vein that occurs as a complication of a peritonsillar abscess. The diagnostic process is then completed with a chest HR-CT, which reveals lung density and excavation areas suggesting tuberculosis. Blood culture reveals the presence of Veillonella Parvula (an anaerobic gram-negative coccus), sputum culture reveals the presence of some colonies of Enterobacter cloacae complex, real-time PCR examination on sputum reveals the presence of Streptococcus Pneumoniae and the borderline presence of rhinovirus. Microbiologists, after these results and neck and chest CT with a contrast agent, agree with the diagnosis of suspected LS at an early stage: a septic dissemination fortunately limited only to the neck and lungs region.
本临床病例呈现了一名38岁年轻女性患勒米尔综合征(LS)的罕见病例。她因高热和咽喉疼痛来到急诊科,使用克拉霉素、头孢曲松和可的松进行抗生素治疗两周后病情仍未缓解。采血时发现明显的白细胞增多,鉴于喉咙剧痛,需要听取耳鼻喉科医生的建议。由于扁桃体脓肿,耳鼻喉科医生认为有必要进行颈部增强CT检查。CT显示颈静脉和左锁骨下静脉血栓形成,血管周围软组织增厚;这些发现提示勒米尔综合征:一种作为扁桃体周围脓肿并发症出现的颈静脉化脓性血栓性静脉炎。随后通过胸部高分辨率CT完成诊断过程,该检查显示肺部有密度和空洞区域,提示患有肺结核。血培养显示存在小韦荣球菌(一种厌氧革兰氏阴性球菌),痰培养显示存在阴沟肠杆菌复合体的一些菌落,痰的实时PCR检查显示存在肺炎链球菌以及鼻病毒的临界存在。微生物学家在得到这些结果以及颈部和胸部增强CT检查结果后,认同早期疑似LS的诊断:一种化脓性播散,幸运的是仅局限于颈部和肺部区域。