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利用益生菌食品:通过肠道健康管理癌症。

Harnessing probiotic foods: managing cancer through gut health.

作者信息

Thapa Devika, Kumar Vijay, Naik Bindu, Kumar Vivek, Gupta Arun Kumar, Mohanta Yugal Kishore, Mishra Bishwambhar, Rustagi Sarvesh

机构信息

Department of Food Science and Technology, Graphic Era Deemed to be University, Clement Town, Dehradun, Uttarakhand 248002 India.

Himalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand 248140 India.

出版信息

Food Sci Biotechnol. 2024 Jun 28;33(9):2141-2160. doi: 10.1007/s10068-024-01638-5. eCollection 2024 Jul.

Abstract

UNLABELLED

One of the greatest threats to global health is cancer. Probiotic foods have been shown to have therapeutic promise in the management of cancer, even though traditional treatments such as radiation therapy, chemotherapy, and surgery are still essential. The generation of anticarcinogenic compounds, immune system stimulation, and gut microbiota regulation are a few ways that probiotics when taken in sufficient quantities, might help health. The purpose of this review is to examine the therapeutic potential of probiotic foods in the management of cancer. Research suggests that certain strains of probiotics have anticancer effects by preventing the growth of cancer cells, triggering apoptosis, and reducing angiogenesis in new tumors. Probiotics have shown promise in mitigating treatment-related adverse effects, such as diarrhea, mucositis, and immunosuppression caused by chemotherapy, improving the general quality of life for cancer patients. However, there are several factors, such as patient-specific features, cancer subtype, and probiotic strain type and dosage, which affect how effective probiotic therapies are in managing cancer. More research is necessary to find the long-term safety and efficacy characteristics of probiotics as well as to clarify the best ways to incorporate them into current cancer treatment methods.

GRAPHICAL ABSTRACT

Graphical representation showing the role of probiotic foods in cancer management.

摘要

未标注

癌症是全球健康面临的最大威胁之一。尽管放射治疗、化疗和手术等传统治疗方法仍然至关重要,但益生菌食品已被证明在癌症管理方面具有治疗前景。产生抗癌化合物、刺激免疫系统和调节肠道微生物群是大量摄入益生菌可能有助于健康的几种方式。本综述的目的是研究益生菌食品在癌症管理中的治疗潜力。研究表明,某些益生菌菌株通过阻止癌细胞生长、触发细胞凋亡和减少新肿瘤中的血管生成而具有抗癌作用。益生菌在减轻治疗相关的不良反应方面已显示出前景,如化疗引起的腹泻、粘膜炎和免疫抑制,改善癌症患者的总体生活质量。然而,有几个因素,如患者的特定特征、癌症亚型以及益生菌菌株类型和剂量,会影响益生菌疗法在癌症管理中的有效性。需要更多的研究来确定益生菌的长期安全性和有效性特征,并阐明将它们纳入当前癌症治疗方法的最佳方式。

图形摘要

显示益生菌食品在癌症管理中作用的图形表示。

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