Ahmad Armeen, Roplekar Sudeep, Podlasek Anna
Radiology, Prime Hospital, Dubai, ARE.
Radiological Sciences, University of Nottingham, Nottingham, GBR.
Cureus. 2024 Jul 12;16(7):e64398. doi: 10.7759/cureus.64398. eCollection 2024 Jul.
Background Congenital anomalies of the coronary artery anatomy (CAAs) encompass a spectrum of disorders, often asymptomatic but potentially carrying severe clinical implications such as arrhythmia, chest pain, myocardial infarction, or sudden death. The estimated prevalence of CAAs in the general population ranges from 0.3% to 1.3%, with underdiagnosis in asymptomatic individuals. Multidetector computed tomography angiography (CTA) has emerged as a vital non-invasive tool for diagnosing and characterising CAAs, offering improved visualisation and aiding in appropriate management decisions. This study aims to analyse the spectrum of CAAs in a tertiary care setting, focusing on imaging features, prevalence, and potential clinical significance, utilising data from patients who underwent multidetector CTA. Methodology A single-centre, retrospective analysis of consecutive coronary angiograms over a five-year period identified patients with CAAs, with imaging conducted using a 128-slice, single-source CT scanner. Detailed imaging evaluation was performed by experienced radiologists, with anomalies classified according to established criteria. Results Among 756 coronary CTA examinations analysed, 37 instances of anomalous coronary vessels were identified. The study revealed a diverse range of anomalies, including myocardial bridging, anomalous origin of coronary arteries, and extracardiac abnormalities. Conclusions This study contributes valuable insights into the prevalence and imaging features of CAAs, enhancing our understanding of these anomalies and guiding improved patient outcomes in cardiovascular care. Future research should focus on elucidating pathophysiological mechanisms and establishing multicenter registries to address the challenges associated with studying these infrequent but clinically significant anomalies.
背景 冠状动脉解剖结构先天性异常(CAAs)涵盖一系列疾病,通常无症状,但可能具有严重的临床意义,如心律失常、胸痛、心肌梗死或猝死。一般人群中CAAs的估计患病率为0.3%至1.3%,无症状个体存在诊断不足的情况。多排螺旋计算机断层扫描血管造影(CTA)已成为诊断和表征CAAs的重要非侵入性工具,可提供更好的可视化效果并有助于做出适当的管理决策。本研究旨在利用接受多排CTA检查的患者数据,分析三级医疗环境中CAAs的范围,重点关注成像特征、患病率和潜在临床意义。
方法 对五年期间连续的冠状动脉造影进行单中心回顾性分析,以确定患有CAAs的患者,使用128层单源CT扫描仪进行成像。由经验丰富的放射科医生进行详细的成像评估,根据既定标准对异常情况进行分类。
结果 在分析的756例冠状动脉CTA检查中,发现37例冠状动脉血管异常。该研究揭示了多种异常情况,包括心肌桥、冠状动脉异常起源和心外异常。
结论 本研究为CAAs的患病率和成像特征提供了有价值的见解,增强了我们对这些异常情况的理解,并指导改善心血管护理中的患者预后。未来的研究应侧重于阐明病理生理机制,并建立多中心登记处,以应对研究这些罕见但具有临床意义的异常情况所带来的挑战。