Cergan Romica, Berghi Ovidiu, Dumitru Mihai, Vrinceanu Daniela, Manole Felicia, Musat Gabriela Cornelia, Oancea Alina Lavinia Antoaneta, Serboiu Crenguta
Anatomy Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Allergology Department, Saint Mary Clinics and Laboratories, 011013 Bucharest, Romania.
Life (Basel). 2025 Mar 15;15(3):469. doi: 10.3390/life15030469.
The present scoping review underlines the molecular interplay between allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and interleukin-8 (IL-8). A query of PubMed database resulted in the inclusion of 34 articles in the final analysis of this scoping review. IL-8 is one interconnecting immune mediator in the physiopathology of AR and CRS. An influx of cytokines, such as interleukin (IL)-4 and IL-13, occurs from mast cells, four to six hours after the initial response signifying the development of the late-phase response allowing the entrance of eosinophils, basophils, and T-lymphocytes at the level of nasal mucosa. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease that occurs in the mucosa of the nasal cavity and sinuses with two external phenotypes, but with molecular mechanisms that overlap with allergic rhinitis. Interleukin 8 induces neutrophil chemokinetic movement providing a chemotactic or directional cue. Clinical and fundamental studies established an implication of IL-8 in the disease mechanism of allergic rhinitis and CRSwNP. Moreover, there is still missing a randomized, large-cohort study with three patients groups (normal control, AR, CRSwNP) that analyzes the impact of IL-8 simultaneously. Future possible developments could focus on IL-8 as possible target for biologic treatments.
本综述强调了变应性鼻炎（AR）、伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）与白细胞介素-8（IL-8）之间的分子相互作用。对PubMed数据库的检索结果最终纳入了34篇文章用于本综述的分析。IL-8是AR和CRS病理生理过程中的一种相互关联的免疫介质。在初始反应后的4至6小时，肥大细胞会释放细胞因子，如白细胞介素（IL）-4和IL-13，这意味着迟发相反应的发生，使得嗜酸性粒细胞、嗜碱性粒细胞和T淋巴细胞进入鼻黏膜。慢性鼻-鼻窦炎（CRS）是一种发生在鼻腔和鼻窦黏膜的慢性炎症性疾病，有两种外在表型，但其分子机制与变应性鼻炎重叠。白细胞介素8诱导中性粒细胞化学趋动，提供趋化或定向信号。临床和基础研究证实IL-8在变应性鼻炎和CRSwNP的发病机制中起作用。此外，目前仍缺乏一项纳入三个患者组（正常对照组、AR组、CRSwNP组）的随机大样本队列研究，以同时分析IL-8的影响。未来可能的发展方向可能聚焦于将IL-8作为生物治疗的潜在靶点。
